InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gabra4

Summary

InnateDB Gene

IDBG-169057.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gabra4

Gene Name

gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4

Synonyms

Gabra-4

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029211

Encoded Proteins

IDBP-169059

gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000109158:
Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1). Alternatively spliced transcript variants encoding different isoforms have been found in this gene.[provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:71569734-71658308

Strand

Reverse strand

Band

C3.2

Transcripts

ENSMUST00000031121

ENSMUSP00000031121

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004890	GABA-A receptor activity
GO:0005230	extracellular ligand-gated ion channel activity
GO:0005254	chloride channel activity

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0007214	gamma-aminobutyric acid signaling pathway
GO:0007417	central nervous system development
GO:1902476	chloride transmembrane transport
GO:2001023	regulation of response to drug