Version 5.4
Mus musculus Gene: Lpcat1
Summary
InnateDB Gene IDBG-165608.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lpcat1
Gene Name lysophosphatidylcholine acyltransferase 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000021608
Encoded Proteins
IDBP-165610
lysophosphatidylcholine acyltransferase 1
IDBP-540522
lysophosphatidylcholine acyltransferase 1
IDBP-538560
lysophosphatidylcholine acyltransferase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000153395:
Lysophosphatidylcholine (LPC) acyltransferase (LPCAT; EC 2.3.1.23) catalyzes the conversion of LPC to phosphatidylcholine (PC) in the remodeling pathway of PC biosynthesis (Nakanishi et al., 2006 [PubMed 16704971]).[supplied by OMIM, May 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:73467197-73516422
Strand Forward strand
Band C1
Transcripts
ENSMUST00000022099 ENSMUSP00000022099
ENSMUST00000123766 ENSMUSP00000117965
ENSMUST00000147566 ENSMUSP00000117238
ENSMUST00000133791
ENSMUST00000140431
ENSMUST00000124627
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0016746 transferase activity, transferring acyl groups
GO:0047159 1-alkenylglycerophosphocholine O-acyltransferase activity
GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity
GO:0047191 1-alkylglycerophosphocholine O-acyltransferase activity
GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity
Biological Process
GO:0008152 metabolic process
GO:0008654 phospholipid biosynthetic process
GO:0036151 phosphatidylcholine acyl-chain remodeling
GO:0043129 surfactant homeostasis
GO:0045732 positive regulation of protein catabolic process
GO:0060041 retina development in camera-type eye
GO:2001246 negative regulation of phosphatidylcholine biosynthetic process
Cellular Component
GO:0000139 Golgi membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005811 lipid particle
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000153395
View Gene Order
ENSBTAG00000000944
Not yet available
Pathways
NETPATH
REACTOME
REACT_199038
Acyl chain remodelling of PC pathway
REACT_199039
Acyl chain remodelling of PG pathway
REACT_256522
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_237947
Triglyceride Biosynthesis pathway
REACT_188641
Glycerophospholipid biosynthesis pathway
REACT_188640
Synthesis of PA pathway
REACT_188643
Phospholipid metabolism pathway
KEGG
mmu00564
Glycerophospholipid metabolism pathway
mmu00565
Ether lipid metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_120829
Acyl chain remodelling of PC pathway
REACT_120906
Synthesis of PA pathway
REACT_121324
Acyl chain remodelling of PG pathway
REACT_1190
Triglyceride Biosynthesis pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_121401
Glycerophospholipid biosynthesis pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00564
Glycerophospholipid metabolism pathway
hsa00565
Ether lipid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.284649 Mm.394897
RefSeq NM_145376 XM_006517188 XM_006517189
OMIM
CCDS CCDS36726
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca