InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lpcat1

Summary

InnateDB Protein

IDBP-165610.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lpcat1

Protein Name

lysophosphatidylcholine acyltransferase 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022099

InnateDB Gene

IDBG-165608 (Lpcat1)

Protein Structure

UniProt Annotation

Function

Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-independent. Mediates the conversion of 1-acyl-sn-glycero-3-phosphocholine (LPC) into phosphatidylcholine (PC). Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively. May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology. {ECO:0000269PubMed:16704971, ECO:0000269PubMed:18156367, ECO:0000269PubMed:18285344}.

Subcellular Localization

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Lipid droplet {ECO:0000250}. Note=May adopt a monotopic topology when embedded in the lipid monolayer of the lipid droplet, with both termini exposed to the cytoplasm. {ECO:0000250}.

Disease Associations

Tissue Specificity

Predominantly expressed in lung where it is enriched in alveolar type II cells. Expressed at lower levels in spleen and brain. Also detected in erythroleukemic cells and reticulocytes. Weakly or not expressed in other tissues. {ECO:0000269PubMed:16704971, ECO:0000269PubMed:16864775, ECO:0000269PubMed:18156367}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0016746	transferase activity, transferring acyl groups
GO:0047159	1-alkenylglycerophosphocholine O-acyltransferase activity
GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity
GO:0047191	1-alkylglycerophosphocholine O-acyltransferase activity
GO:0047192	1-alkylglycerophosphocholine O-acetyltransferase activity

Biological Process

GO:0008152	metabolic process
GO:0008654	phospholipid biosynthetic process
GO:0036151	phosphatidylcholine acyl-chain remodeling
GO:0043129	surfactant homeostasis
GO:0045732	positive regulation of protein catabolic process
GO:0060041	retina development in camera-type eye
GO:2001246	negative regulation of phosphatidylcholine biosynthetic process

Cellular Component

GO:0000139	Golgi membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0005811	lipid particle
GO:0016020	membrane
GO:0016021	integral component of membrane