Mus musculus Gene: Lgmn | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-165744.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Lgmn | ||||||||||||||||||||||
Gene Name | legumain | ||||||||||||||||||||||
Synonyms | AEP; AI746452; AU022324; Prsc1 | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000021190 | ||||||||||||||||||||||
Encoded Proteins |
legumain
legumain
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||
Summary |
Lgmn is an asparagine endopeptidase that removes the majority of the Tlr9 ectodomain, and this catalytic cleavage is required for Tlr9 endolysosome signalling in response to DNA.
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InnateDB Annotation from Orthologs | |||||||||||||||||||||||
Summary |
[Homo sapiens] LGMN is an asparagine endopeptidase that removes the majority of the TLR9 ectodomain, and this catalytic cleavage is required for TLR9 endolysosome signalling in response to DNA. (Demonstrated in murine model)
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Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100600:
This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 12:102394084-102439813 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | E | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Innate Immune System pathway
Trafficking and processing of endosomal TLR pathway
Vitamin D (calciferol) metabolism pathway
Metabolism pathway
Immune System pathway
Metabolism of lipids and lipoproteins pathway
MHC class II antigen presentation pathway
Toll-Like Receptors Cascades pathway
Adaptive Immune System pathway
Metabolism of steroid hormones and vitamin D pathway
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KEGG |
Antigen processing and presentation pathway
Lysosome pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Trafficking and processing of endosomal TLR pathway
MHC class II antigen presentation pathway
Vitamin D (calciferol) metabolism pathway
Metabolism of lipids and lipoproteins pathway
Innate Immune System pathway
Metabolism of steroid hormones and vitamin D pathway
Toll-Like Receptors Cascades pathway
Adaptive Immune System pathway
Immune System pathway
Metabolism pathway
Trafficking and processing of endosomal TLR pathway
Immune System pathway
Toll-Like Receptors Cascades pathway
MHC class II antigen presentation pathway
Metabolism of lipids and lipoproteins pathway
Vitamin D (calciferol) metabolism pathway
Metabolism of steroid hormones and vitamin D pathway
Metabolism pathway
Adaptive Immune System pathway
Innate Immune System pathway
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KEGG |
Antigen processing and presentation pathway
Lysosome pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | O89017 | ||||||||||||||||||||||
TrEMBL | A2RTI3 Q3UE99 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 19141 | ||||||||||||||||||||||
UniGene | Mm.17185 Mm.471878 | ||||||||||||||||||||||
RefSeq | NM_011175 XM_006515604 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS26119 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | MGI:1330838 | ||||||||||||||||||||||
MGI Symbol | Lgmn | ||||||||||||||||||||||
EMBL | AF044266 AJ000990 AK149666 BC132515 BC132519 CH466549 | ||||||||||||||||||||||
GenPept | AAF21659 AAI32516 AAI32520 BAE29012 CAA04439 EDL18865 | ||||||||||||||||||||||
RNA Seq Atlas | 19141 | ||||||||||||||||||||||