InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: LGMN

Summary

InnateDB Gene

IDBG-17093.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LGMN

Gene Name

legumain

Synonyms

AEP; LGMN1; PRSC1

Species

Homo sapiens

Ensembl Gene

ENSG00000100600

Encoded Proteins

IDBP-17095

legumain

IDBP-244009

legumain

IDBP-587218

legumain

IDBP-593733

legumain

IDBP-600623

legumain

IDBP-586218

legumain

IDBP-600820

legumain

IDBP-588350

legumain

IDBP-601103

legumain

IDBP-602718

legumain

IDBP-596116

legumain

IDBP-583361

legumain

IDBP-599840

legumain

IDBP-588236

legumain

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21402738

LGMN is an asparagine endopeptidase that removes the majority of the TLR9 ectodomain, and this catalytic cleavage is required for TLR9 endolysosome signalling in response to DNA. (Demonstrated in murine model)

InnateDB Annotation from Orthologs

Summary

PMID 21402738

[Mus musculus] Lgmn is an asparagine endopeptidase that removes the majority of the Tlr9 ectodomain, and this catalytic cleavage is required for Tlr9 endolysosome signalling in response to DNA.

Entrez Gene

Summary

This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:92703807-92748702

Strand

Reverse strand

Band

q32.12

Transcripts

ENST00000334869	ENSP00000334052
ENST00000393218	ENSP00000376911
ENST00000555699	ENSP00000451861
ENST00000555169	ENSP00000451854
ENST00000557434	ENSP00000452572
ENST00000557609	ENSP00000451507
ENST00000556790
ENST00000557725
ENST00000556097	ENSP00000451746
ENST00000554189	ENSP00000450483
ENST00000553802	ENSP00000450854
ENST00000557694
ENST00000554397	ENSP00000450677
ENST00000554919	ENSP00000451916
ENST00000554080	ENSP00000452268
ENST00000553371	ENSP00000451797
ENST00000557315
ENST00000553918	ENSP00000450619
ENST00000557034

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Experimentally validated
Total	15 [view]
Protein-Protein	14 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0008233	peptidase activity

Biological Process

GO:0002224	toll-like receptor signaling pathway
GO:0003014	renal system process
GO:0006508	proteolysis
GO:0008202	steroid metabolic process
GO:0010447	response to acidity
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0032801	receptor catabolic process
GO:0040015	negative regulation of multicellular organism growth
GO:0042359	vitamin D metabolic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0051603	proteolysis involved in cellular protein catabolic process
GO:1901185	negative regulation of ERBB signaling pathway