InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Havcr2

Summary

InnateDB Gene

IDBG-165782.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Havcr2

Gene Name

hepatitis A virus cellular receptor 2

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020399

Encoded Proteins

IDBP-165784

hepatitis A virus cellular receptor 2

IDBP-262836

hepatitis A virus cellular receptor 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21637332

Havcr2 is constitutively expressed on human resting monocytes/macrophages and functions as a cap to block Il12, which is a key pro-inflammatory cytokine linking innate and adaptive immune responses. Havcr2 plays a crucial role in the negative regulation of innate immune responses through crosstalk with Pdcd1 and Socs1 to limit Stat1 phosphorylation in HCV infection. (Demonstrated in human)

InnateDB Annotation from Orthologs

Summary

PMID 21637332

[Homo sapiens] HAVCR2 is constitutively expressed on human resting monocytes/macrophages and functions as a cap to block IL12, which is a key pro-inflammatory cytokine linking innate and adaptive immune responses. HAVCR2 plays a crucial role in the negative regulation of innate immune responses through crosstalk with PDCD1 and SOCS1 to limit STAT1 phosphorylation in HCV infection.

PMID 23967307

[Homo sapiens] TLR activation promotes HAVCR2 and LGALS9 association within the same macrophage to differentially regulate IL12/IL23 expressions via STAT3 phosphorylation.

PMID 25772938

[Homo sapiens] Hepatitis C virus (HCV)-induced, MIR155-regulated HAVCR2 expression regulates natural killer cell function, suggesting a novel mechanism for balancing immune clearance and immune injury during chronic viral infection.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135077:
The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:46454935-46481255

Strand

Forward strand

Band

B1.1

Transcripts

ENSMUST00000020668	ENSMUSP00000020668
ENSMUST00000109229	ENSMUSP00000104852

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0045087

innate immune response (InnateDB)

Cellular Component

GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Gene ID

Gene Order

ENSG00000135077

View Gene Order

Cross-References

SwissProt

TrEMBL

D3Z3I4

UniProt Splice Variant

Entrez Gene

171285

UniGene

Mm.72168

RefSeq

NM_134250

OMIM

CCDS

CCDS36135

HPRD

IMGT

MGI ID

MGI:2159682

MGI Symbol

Havcr2

EMBL

AL669948

GenPept

RNA Seq Atlas

171285