InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pik3ap1

Summary

InnateDB Gene

IDBG-165835.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pik3ap1

Gene Name

phosphoinositide-3-kinase adaptor protein 1

Synonyms

1810044J04Rik; BCAP

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025017

Encoded Proteins

IDBP-165837

phosphoinositide-3-kinase adaptor protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20728433

Pik3ap1 acts as a negative regulator of TLR-induced production of IL6 and IL10 in macrophages in response to LPS stimulation.

InnateDB Annotation from Orthologs

Summary

PMID 20728433

[Homo sapiens] PIK3AP1 acts as a negative regulator of TLR-induced production of IL6 and IL10 in macrophages in response to LPS stimulation. (Demonstrated in murine model)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000155629:

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:41274218-41385070

Strand

Reverse strand

Band

Transcripts

ENSMUST00000059672

ENSMUSP00000052777

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding
GO:0042802	identical protein binding

Biological Process

GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0034122	negative regulation of toll-like receptor signaling pathway
GO:0034123	positive regulation of toll-like receptor signaling pathway
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034154	toll-like receptor 7 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0050727	regulation of inflammatory response