InnateDB Protein
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IDBP-165837.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Pik3ap1
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Protein Name
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phosphoinositide-3-kinase adaptor protein 1
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Synonyms
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1810044J04Rik; BCAP;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000052777
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InnateDB Gene
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IDBG-165835 (Pik3ap1)
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Protein Structure
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Function |
Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL. {ECO:0000269PubMed:11781242, ECO:0000269PubMed:11877477, ECO:0000269PubMed:12833156, ECO:0000269PubMed:18025150, ECO:0000269PubMed:18337558, ECO:0000269PubMed:22187458, ECO:0000269PubMed:22187460}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:22187458}. Cell membrane {ECO:0000305PubMed:22187458}; Peripheral membrane protein {ECO:0000305PubMed:22187458}.
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Disease Associations |
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Tissue Specificity |
Predominantly expressed in spleen (at protein level). Expressed at lower levels in thymus, liver and lung. Expressed in B-cells, macrophages and natural killer (NK) cells. {ECO:0000269PubMed:11163197, ECO:0000269PubMed:18337558}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated |
Total |
8
[view]
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Protein-Protein |
8
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
5 [view]
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Molecular Function |
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Biological Process |
GO:0014068
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positive regulation of phosphatidylinositol 3-kinase signaling
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GO:0034122
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negative regulation of toll-like receptor signaling pathway
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GO:0034123
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positive regulation of toll-like receptor signaling pathway
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GO:0034134
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toll-like receptor 2 signaling pathway
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GO:0034142
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toll-like receptor 4 signaling pathway
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GO:0034154
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toll-like receptor 7 signaling pathway
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GO:0034162
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toll-like receptor 9 signaling pathway
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GO:0045087
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innate immune response (InnateDB)
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GO:0050727
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regulation of inflammatory response
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Cellular Component |
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PDB ID |
MGI:1933177
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InterPro |
IPR020683
Ankyrin repeat-containing domain
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PFAM |
PF11929
PF12796
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9EQ32
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PhosphoSite |
PhosphoSite-Q9EQ32
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
83490
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UniGene |
Mm.222266
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RefSeq |
NP_113553
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MGI ID |
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MGI Symbol |
Pik3ap1
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OMIM |
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CCDS |
CCDS37987
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HPRD |
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IMGT |
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EMBL |
AF293806
AK087722
AK089785
AK150114
AK153548
AK170130
AK170925
AK171021
BC113141
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GenPept |
AAG48584
AAI13142
BAC39980
BAC40962
BAE29318
BAE32085
BAE41584
BAE42118
BAE42191
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