InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tlr1

Summary

InnateDB Gene

IDBG-165889.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tlr1

Gene Name

toll-like receptor 1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000044827

Encoded Proteins

IDBP-165891

toll-like receptor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21439957

Tlr1 :: Tlr2 dimeric pairs recognize malarial glycosylphosphatidylinositols (GPI) to initiates intracellular signalling and the production of pro-inflammatory cytokines.

PMID 22778390

Tlr1 is a critical innate receptor for protective intestinal T(H)17 immunity against Yersinia enterocolitica.

PMID 23443468

TLR1 in intestinal epithelium mediates activation and recruitment of dendritic cells to mount mucosal immunity against Yersinia enterocolitica.

InnateDB Annotation from Orthologs

Summary

PMID 18635889

[Homo sapiens] TLR1 polymorphisms affect innate immune responses and outcomes in sepsis.

PMID 11932926

[Homo sapiens] TLR1 restrains potentially dangerous innate response to LPS by binding to TLR4 and preventing the formation of active signalling complexes.

PMID 12077222

[Homo sapiens] TLR1 interacts with TLR2 to recognize the lipid configuration of the native mycobacterial lipoprotein as well as several triacylated lipopeptides.

PMID 12697090

[Homo sapiens] TLR1 and TLR6 are involved in the discrimination of a subtle difference between triacyl and diacyl lipopeptides through interaction with TLR2.

PMID 21439957

[Homo sapiens] TLR1 :: TLR2 dimeric pairs recognize malarial glycosylphosphatidylinositols (GPI) to initiates intracellular signalling and the production of pro-inflammatory cytokines.

PMID 22778390

[Homo sapiens] TLR1 is a critical innate receptor for protective intestinal T(H)17 immunity against Yersinia enterocolitica. (Demonstrated in mice)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000174125:
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:64924811-64932761

Strand

Reverse strand

Band

C3.1

Transcripts

ENSMUST00000059349

ENSMUSP00000060793

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding
GO:0042497	triacyl lipopeptide binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0002224	toll-like receptor signaling pathway
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0006952	defense response
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007165	signal transduction
GO:0007250	activation of NF-kappaB-inducing kinase activity
GO:0034130	toll-like receptor 1 signaling pathway
GO:0042116	macrophage activation
GO:0042495	detection of triacyl bacterial lipopeptide
GO:0042535	positive regulation of tumor necrosis factor biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045410	positive regulation of interleukin-6 biosynthetic process
GO:0050707	regulation of cytokine secretion
GO:0071727	cellular response to triacyl bacterial lipopeptide

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030670	phagocytic vesicle membrane
GO:0035354	Toll-like receptor 1-Toll-like receptor 2 protein complex
GO:0045335	phagocytic vesicle

Orthologs

Species

Homo sapiens

Gene ID

Gene Order

ENSG00000174125

View Gene Order

Pathways

NETPATH

REACTOME

KEGG

mmu04620

Toll-like receptor signaling pathway pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04620

Toll-like receptor signaling pathway pathway

INOH

PID NCI

toll_endogenous_pathway

Endogenous TLR signaling

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.273024

RefSeq

NM_001276445 NM_030682 XM_006503850 XM_006503851 XM_006503852 XM_006503853 XM_006503854 XM_006503855 XM_006503856

OMIM

CCDS

CCDS19302

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas