InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tlr6

Summary

InnateDB Gene

IDBG-165921.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tlr6

Gene Name

toll-like receptor 6

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000051498

Encoded Proteins

IDBP-165923

toll-like receptor 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21482737

Tlr2::Tlr6 synergistically interacts with Tlr9 in lung epithelium to induce rapid pathogen killing, and can be used as a therapeutic target to treat otherwise lethal pneumonia.

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:64953106-64960048

Strand

Reverse strand

Band

C3.1

Transcripts

ENSMUST00000062315

ENSMUSP00000062096

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	3 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding
GO:0042498	diacyl lipopeptide binding
GO:0046982	protein heterodimerization activity
GO:0071723	lipopeptide binding

Biological Process

GO:0002224	toll-like receptor signaling pathway
GO:0002282	microglial cell activation involved in immune response
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007165	signal transduction
GO:0034150	toll-like receptor 6 signaling pathway
GO:0042088	T-helper 1 type immune response
GO:0042496	detection of diacyl bacterial lipopeptide
GO:0042742	defense response to bacterium
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043507	positive regulation of JUN kinase activity
GO:0045084	positive regulation of interleukin-12 biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045410	positive regulation of interleukin-6 biosynthetic process
GO:0046209	nitric oxide metabolic process
GO:0050707	regulation of cytokine secretion
GO:0052033	pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response
GO:0071726	cellular response to diacyl bacterial lipopeptide