InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tlr6

Summary

InnateDB Protein

IDBP-165923.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tlr6

Protein Name

toll-like receptor 6

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000062096

InnateDB Gene

IDBG-165921 (Tlr6)

Protein Structure

UniProt Annotation

Function

Participates in the innate immune response to Gram- positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Cooperates with TLR2 for the cellular activation. {ECO:0000269PubMed:19931471}.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Detected in thymus, spleen, ovary and lung.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	3 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding
GO:0042498	diacyl lipopeptide binding
GO:0046982	protein heterodimerization activity
GO:0071723	lipopeptide binding

Biological Process

GO:0002224	toll-like receptor signaling pathway
GO:0002282	microglial cell activation involved in immune response
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007165	signal transduction
GO:0034150	toll-like receptor 6 signaling pathway
GO:0042088	T-helper 1 type immune response
GO:0042496	detection of diacyl bacterial lipopeptide
GO:0042742	defense response to bacterium
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043507	positive regulation of JUN kinase activity
GO:0045084	positive regulation of interleukin-12 biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045410	positive regulation of interleukin-6 biosynthetic process
GO:0046209	nitric oxide metabolic process
GO:0050707	regulation of cytokine secretion
GO:0052033	pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response
GO:0071726	cellular response to diacyl bacterial lipopeptide

Cellular Component

GO:0016021	integral component of membrane
GO:0030670	phagocytic vesicle membrane
GO:0035355	Toll-like receptor 2-Toll-like receptor 6 protein complex

Protein Structure and Domains

PDB ID

MGI:1341296

InterPro

IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
IPR000483 Cysteine-rich flanking region, C-terminal
IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
IPR017241 Toll-like receptor

PFAM

PF01582
PF13676
PF01463
PF00560
PF13504
PF13855

PRINTS

PIRSF

PIRSF037595

SMART

SM00255
SM00082
SM00369

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt