Version 5.4
Mus musculus Gene: Bst2
Summary
InnateDB Gene IDBG-165924.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Bst2
Gene Name bone marrow stromal cell antigen 2
Synonyms 2310015I10Rik; Bst-2; C87040; CD317; DAMP-1; GREG
Species Mus musculus
Ensembl Gene ENSMUSG00000046718
Encoded Proteins
IDBP-165926
bone marrow stromal cell antigen 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22072710
Bst2 is a broad spectrum effector of the innate immune response to viral infection that is antagonized by the human immunodeficiency virus (HIV) Vpu protein to evade innate immune system detection. (Demonstrated in human)
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 8:71534264-71537437
Strand Reverse strand
Band B3.3
Transcripts
ENSMUST00000051672 ENSMUSP00000051921
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0008191 metalloendopeptidase inhibitor activity
GO:0042803 protein homodimerization activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0002737 negative regulation of plasmacytoid dendritic cell cytokine production
GO:0007165 signal transduction
GO:0009615 response to virus
GO:0010951 negative regulation of endopeptidase activity
GO:0030308 negative regulation of cell growth
GO:0030336 negative regulation of cell migration
GO:0032956 regulation of actin cytoskeleton organization
GO:0034341 response to interferon-gamma
GO:0035455 response to interferon-alpha
GO:0035456 response to interferon-beta
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045071 negative regulation of viral genome replication
GO:0045087 innate immune response (InnateDB)
GO:0051607 defense response to virus
GO:1901253 negative regulation of intracellular transport of viral material
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005770 late endosome
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0031225 anchored component of membrane
GO:0045121 membrane raft
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q8R2Q8
TrEMBL
UniProt Splice Variant
Entrez Gene 69550
UniGene
RefSeq NM_198095
OMIM
CCDS CCDS22397
HPRD
IMGT
MGI ID MGI:1916800
MGI Symbol Bst2
EMBL AK009361 AK154399 BC027328 BC056638 BC087949
GenPept AAH27328 AAH56638 AAH87949 BAC25254 BAE32560
RNA Seq Atlas 69550

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca