InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bst2

Summary

InnateDB Protein

IDBP-165926.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bst2

Protein Name

bone marrow stromal cell antigen 2

Synonyms

2310015I10Rik; Bst-2; C87040; CD317; DAMP-1; GREG;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000051921

InnateDB Gene

IDBG-165924 (Bst2)

Protein Structure

UniProt Annotation

Function

IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1 (HIV-1), mouse mammary tumor virus (MMTV) and murine leukemia virus (MLV), filoviridae: ebola virus (EBOV), arenaviridae: lassa virus (LASV), and rhabdoviridae: vesicular stomatitis virus (VSV). Can inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration. Can stimulate signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection. Plays a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells. {ECO:0000269PubMed:16920966, ECO:0000269PubMed:19179289, ECO:0000269PubMed:20686043, ECO:0000269PubMed:20702620, ECO:0000269PubMed:21919738, ECO:0000269PubMed:22025715, ECO:0000269PubMed:22284121, ECO:0000269PubMed:22327075}.

Subcellular Localization

Golgi apparatus, trans-Golgi network. Cell membrane; Single-pass type II membrane protein. Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}. Late endosome {ECO:0000250}. Membrane raft {ECO:0000250}. Cytoplasm {ECO:0000250}. Apical cell membrane {ECO:0000250}. Note=Shuttles between the cell membrane, where it is present predominantly in membrane/lipid rafts, and the trans-Golgi network. Forms a complex with MMP14 and localizes to the cytoplasm (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

In naive mice, specifically expressed on type I interferon-producing cells (at protein level). {ECO:0000269PubMed:16920966}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0008191	metalloendopeptidase inhibitor activity
GO:0042803	protein homodimerization activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0002737	negative regulation of plasmacytoid dendritic cell cytokine production
GO:0007165	signal transduction
GO:0009615	response to virus
GO:0010951	negative regulation of endopeptidase activity
GO:0030308	negative regulation of cell growth
GO:0030336	negative regulation of cell migration
GO:0032956	regulation of actin cytoskeleton organization
GO:0034341	response to interferon-gamma
GO:0035455	response to interferon-alpha
GO:0035456	response to interferon-beta
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045071	negative regulation of viral genome replication
GO:0045087	innate immune response (InnateDB)
GO:0051607	defense response to virus
GO:1901253	negative regulation of intracellular transport of viral material

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005770	late endosome
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0031225	anchored component of membrane
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome