Version 5.4
Mus musculus Gene: Unc13a
Summary
InnateDB Gene IDBG-166349.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Unc13a
Gene Name unc-13 homolog A (C. elegans)
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000034799
Encoded Proteins
IDBP-166351
unc-13 homolog A (C. elegans)
IDBP-717410
IDBP-715946
IDBP-716208
IDBP-716172
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130477:
This gene encodes a member of the UNC13 family. UNC13 proteins bind to phorbol esters and diacylglycerol and play important roles in neurotransmitter release at synapses. Single nucleotide polymorphisms in this gene may be associated with sporadic amyotrophic lateral sclerosis. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:71624417-71671757
Strand Reverse strand
Band B3.3
Transcripts
ENSMUST00000030170 ENSMUSP00000030170
ENSMUST00000176426 ENSMUSP00000135032
ENSMUST00000177517 ENSMUSP00000135189
ENSMUST00000175780
ENSMUST00000176777
ENSMUST00000175909 ENSMUSP00000135528
ENSMUST00000177032
ENSMUST00000176127 ENSMUSP00000135578
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019992 diacylglycerol binding
GO:0046872 metal ion binding
Biological Process
GO:0001956 positive regulation of neurotransmitter secretion
GO:0007528 neuromuscular junction development
GO:0016081 synaptic vesicle docking involved in exocytosis
GO:0016188 synaptic vesicle maturation
GO:0035249 synaptic transmission, glutamatergic
GO:0035556 intracellular signal transduction
GO:0048172 regulation of short-term neuronal synaptic plasticity
GO:0050435 beta-amyloid metabolic process
GO:0060384 innervation
Cellular Component
GO:0005737 cytoplasm
GO:0030054 cell junction
GO:0030424 axon
GO:0031594 neuromuscular junction
GO:0042734 presynaptic membrane
GO:0045202 synapse
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000130477
View Gene Order
ENSBTAG00000012682
Not yet available
Cross-References
SwissProt
TrEMBL H3BJZ7
UniProt Splice Variant
Entrez Gene 382018
UniGene Mm.334606 Mm.441808
RefSeq XM_006509691 XM_006509692 XM_006509693 NM_001029873 XM_006509694
OMIM
CCDS CCDS22402
HPRD
IMGT
MGI ID MGI:3051532
MGI Symbol Unc13a
EMBL AC162033
GenPept
RNA Seq Atlas 382018

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca