InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Unc13a

Summary

InnateDB Protein

IDBP-166351.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Unc13a

Protein Name

unc-13 homolog A (C. elegans)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030170

InnateDB Gene

IDBG-166349 (Unc13a)

Protein Structure

UniProt Annotation

Function

Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. Also involved in secretory granule priming in insulin secretion. {ECO:0000269PubMed:10440375, ECO:0000269PubMed:12070347, ECO:0000269PubMed:15988013, ECO:0000269PubMed:16644700, ECO:0000269PubMed:16697276, ECO:0000269PubMed:17267576, ECO:0000269PubMed:17639022}.

Subcellular Localization

Cytoplasm {ECO:0000250UniProtKB:Q62768}. Cell membrane {ECO:0000250UniProtKB:Q62768}; Peripheral membrane protein {ECO:0000250UniProtKB:Q62768}. Cell junction, synapse, presynaptic cell membrane {ECO:0000250UniProtKB:Q62768}; Peripheral membrane protein {ECO:0000250UniProtKB:Q62768}. Note=Localized to the active zone of presynaptic density. Translocated to the plasma membrane in response to phorbol ester binding (By similarity). {ECO:0000250UniProtKB:Q62768}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019992	diacylglycerol binding
GO:0046872	metal ion binding

Biological Process

GO:0001956	positive regulation of neurotransmitter secretion
GO:0007528	neuromuscular junction development
GO:0016081	synaptic vesicle docking involved in exocytosis
GO:0016188	synaptic vesicle maturation
GO:0035249	synaptic transmission, glutamatergic
GO:0035556	intracellular signal transduction
GO:0048172	regulation of short-term neuronal synaptic plasticity
GO:0050435	beta-amyloid metabolic process
GO:0060384	innervation

Cellular Component

GO:0005737	cytoplasm
GO:0030054	cell junction
GO:0030424	axon
GO:0031594	neuromuscular junction
GO:0042734	presynaptic membrane
GO:0045202	synapse

Protein Structure and Domains

PDB ID

MGI:3051532

InterPro

IPR000008 C2 domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
IPR010439 Calcium-dependent secretion activator
IPR019558 Mammalian uncoordinated homology 13, subgroup, domain 2

PFAM

PF00168
PF00130
PF06292
PF10540

PRINTS

PR00360

PIRSF

SMART

SM00239
SM00109

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt