InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rfc1

Summary

InnateDB Gene

IDBG-166380.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rfc1

Gene Name

replication factor C (activator 1) 1

Synonyms

140kDa; Alp145; Recc1; RFC140

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029191

Encoded Proteins

IDBP-166382

replication factor C (activator 1) 1

IDBP-628168

replication factor C (activator 1) 1

IDBP-628170

replication factor C (activator 1) 1

IDBP-628171

replication factor C (activator 1) 1

IDBP-628173

replication factor C (activator 1) 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000035928:
This gene encodes the large subunit of replication factor C, a five subunit DNA polymerase accessory protein, which is a DNA-dependent ATPase required for eukaryotic DNA replication and repair. The large subunit acts as an activator of DNA polymerases, binds to the 3' end of primers, and promotes coordinated synthesis of both strands. It may also have a role in telomere stability. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2011]
This gene encodes the large subunit of replication factor C, a five subunit DNA polymerase accessory protein, which is a DNA-dependent ATPase required for eukaryotic DNA replication and repair. The large subunit acts as an activator of DNA polymerases, binds to the 3\' end of primers, and promotes coordinated synthesis of both strands. It may also have a role in telomere stability. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:65261852-65335670

Strand

Reverse strand

Band

C3.1

Transcripts

ENSMUST00000031092	ENSMUSP00000031092
ENSMUST00000172732	ENSMUSP00000134444
ENSMUST00000172780	ENSMUSP00000133738
ENSMUST00000172660	ENSMUSP00000133457
ENSMUST00000174566
ENSMUST00000173451	ENSMUSP00000134375
ENSMUST00000173994

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	42 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003677	DNA binding
GO:0003689	DNA clamp loader activity
GO:0003690	double-stranded DNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0017111	nucleoside-triphosphatase activity
GO:0019904	protein domain specific binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006200	ATP catabolic process
GO:0006260	DNA replication
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated

Cellular Component

GO:0005634	nucleus
GO:0005663	DNA replication factor C complex
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0030054	cell junction
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome