InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rfc1

Summary

InnateDB Protein

IDBP-166382.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rfc1

Protein Name

replication factor C (activator 1) 1

Synonyms

140kDa; Alp145; Recc1; RFC140;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031092

InnateDB Gene

IDBG-166380 (Rfc1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	42 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003677	DNA binding
GO:0003689	DNA clamp loader activity
GO:0003690	double-stranded DNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0017111	nucleoside-triphosphatase activity
GO:0019904	protein domain specific binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006200	ATP catabolic process
GO:0006260	DNA replication
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated

Cellular Component

GO:0005634	nucleus
GO:0005663	DNA replication factor C complex
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0030054	cell junction
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:97891

InterPro

IPR001357 BRCT domain
IPR003593 AAA+ ATPase domain
IPR003959 ATPase, AAA-type, core
IPR008921 DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal
IPR012178 DNA replication factor C, large subunit
IPR013725 DNA replication factor RFC1, C-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00533
PF12738
PF00004
PF07724
PF13304
PF08519

PRINTS

PIRSF

PIRSF036578

SMART

SM00292
SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt