InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cxcr2

Summary

InnateDB Gene

IDBG-166395.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cxcr2

Gene Name

chemokine (C-X-C motif) receptor 2

Synonyms

CD128; CDw128; Cmkar2; Gpcr16; IL-8rb; IL-8Rh; IL8RA; Il8rb; mIL-8RH

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026180

Encoded Proteins

IDBP-166397

chemokine (C-X-C motif) receptor 2

IDBP-267806

chemokine (C-X-C motif) receptor 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 24651866

In response to adenovirus infection, the IL1A-IL1R1-CXCR2 signalling axis cooperates with complement to recruit Ly-6G+7/4+ polymorphonuclear leukocytes to the splenic marginal zone (MZ) in the proximity of virus-containing MARCO+ residential MZ macrophages, which are subsequently eliminated.

PMID 24755316

Fibrates protect against bacteria�?�induced sepsis by inhibiting LPS�?�mediated ERK phosphorylation and the expression of Adrbk1 (GRK2), thereby preventing Cxcr2 down-regulation on neutrophils.

InnateDB Annotation from Orthologs

Summary

PMID 20818377

[Homo sapiens] IL8RB is a G protein-coupled receptor that mediates NADPH oxidase-independent neutrophil extracellular trap (NET) formation and this G protein-coupled receptor (GPCR) pathway is operative and drug-sensitive in cystic fibrosis lung disease.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000180871:
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:74153989-74161246

Strand

Forward strand

Band

Transcripts

ENSMUST00000027372	ENSMUSP00000027372
ENSMUST00000106899	ENSMUSP00000102512

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004918	interleukin-8 receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004950	chemokine receptor activity
GO:0005515	protein binding
GO:0019959	interleukin-8 binding

Biological Process

GO:0002438	acute inflammatory response to antigenic stimulus
GO:0002690	positive regulation of leukocyte chemotaxis
GO:0006935	chemotaxis
GO:0006968	cellular defense response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0008284	positive regulation of cell proliferation
GO:0010666	positive regulation of cardiac muscle cell apoptotic process
GO:0030593	neutrophil chemotaxis
GO:0030901	midbrain development
GO:0031623	receptor internalization
GO:0033030	negative regulation of neutrophil apoptotic process
GO:0038112	interleukin-8-mediated signaling pathway
GO:0042119	neutrophil activation
GO:0043066	negative regulation of apoptotic process
GO:0043117	positive regulation of vascular permeability
GO:0045087	innate immune response (InnateDB)
GO:0045766	positive regulation of angiogenesis
GO:0070098	chemokine-mediated signaling pathway
GO:0072173	metanephric tubule morphogenesis
GO:0090023	positive regulation of neutrophil chemotaxis