InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cxcr2

Summary

InnateDB Protein

IDBP-267806.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cxcr2

Protein Name

chemokine (C-X-C motif) receptor 2

Synonyms

CD128; CDw128; Cmkar2; Gpcr16; IL-8rb; IL-8Rh; IL8RA; Il8rb; mIL-8RH;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000102512

InnateDB Gene

IDBG-166395 (Cxcr2)

Protein Structure

UniProt Annotation

Function

Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2. {ECO:0000269PubMed:14764687}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004918	interleukin-8 receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004950	chemokine receptor activity
GO:0005515	protein binding
GO:0019959	interleukin-8 binding

Biological Process

GO:0002438	acute inflammatory response to antigenic stimulus
GO:0002690	positive regulation of leukocyte chemotaxis
GO:0006935	chemotaxis
GO:0006968	cellular defense response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0008284	positive regulation of cell proliferation
GO:0010666	positive regulation of cardiac muscle cell apoptotic process
GO:0030593	neutrophil chemotaxis
GO:0030901	midbrain development
GO:0031623	receptor internalization
GO:0033030	negative regulation of neutrophil apoptotic process
GO:0038112	interleukin-8-mediated signaling pathway
GO:0042119	neutrophil activation
GO:0043066	negative regulation of apoptotic process
GO:0043117	positive regulation of vascular permeability
GO:0045766	positive regulation of angiogenesis
GO:0070098	chemokine-mediated signaling pathway
GO:0072173	metanephric tubule morphogenesis
GO:0090023	positive regulation of neutrophil chemotaxis

Cellular Component

GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0042629	mast cell granule

Protein Structure and Domains

PDB ID

MGI:105303

InterPro

IPR000057 CXC chemokine receptor 2
IPR000174 CXC chemokine receptor 1/2
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000355 Chemokine receptor family
IPR001277 CXC chemokine receptor 4
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00573
PR00427
PR00237
PR00657
PR00645

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P35343