Version 5.4
Homo sapiens Gene: OAZ2
Summary
InnateDB Gene IDBG-16677.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OAZ2
Gene Name ornithine decarboxylase antizyme 2
Synonyms AZ2
Species Homo sapiens
Ensembl Gene ENSG00000180304
Encoded Proteins
IDBP-747190
IDBP-747668
IDBP-747683
IDBP-746141
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. The ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. Antizyme expression is auto-regulated by polyamine-enhanced translational frameshifting. The antizyme encoded by this gene inhibits ornithine decarboxylase but does not accelerate its degradation. [provided by RefSeq, Jul 2008]
The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo, however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:64687573-64703281
Strand Reverse strand
Band q22.31
Transcripts
ENST00000326005 ENSP00000463013
ENST00000558194
ENST00000560258 ENSP00000462354
ENST00000559753 ENSP00000463729
ENST00000559912 ENSP00000462192
ENST00000559665
ENST00000560781
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 1 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004857 enzyme inhibitor activity
GO:0005515 protein binding
GO:0008073 ornithine decarboxylase inhibitor activity
Biological Process
GO:0006521 regulation of cellular amino acid metabolic process
GO:0006595 polyamine metabolic process
GO:0034641 cellular nitrogen compound metabolic process
GO:0043086 negative regulation of catalytic activity
GO:0044281 small molecule metabolic process
GO:0045732 positive regulation of protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040652
View Gene Order
ENSBTAG00000015806
Not yet available
Pathways
NETPATH
REACTOME
REACT_13565
Regulation of ornithine decarboxylase (ODC) pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.597677 Hs.634675 Hs.743591 Hs.74563
RefSeq NM_001301302 NM_002537
HUGO
OMIM
CCDS CCDS58372
HPRD 11966
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca