InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: OAZ2

Summary

InnateDB Protein

IDBP-747190.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OAZ2

Protein Name

Synonyms

AZ2;

Species

Homo sapiens

Ensembl Protein

ENSP00000463013

InnateDB Gene

IDBG-16677 (OAZ2)

Protein Structure

UniProt Annotation

Function

Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake by binding to ODC1 without promoting its degradation (PubMed:17900240). Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol. {ECO:0000269PubMed:17900240}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	1 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004857	enzyme inhibitor activity
GO:0005515	protein binding
GO:0008073	ornithine decarboxylase inhibitor activity

Biological Process

GO:0006521	regulation of cellular amino acid metabolic process
GO:0006595	polyamine metabolic process
GO:0034641	cellular nitrogen compound metabolic process
GO:0043086	negative regulation of catalytic activity
GO:0044281	small molecule metabolic process
GO:0045732	positive regulation of protein catabolic process