InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Nr5a1

Summary

InnateDB Gene

IDBG-166784.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nr5a1

Gene Name

nuclear receptor subfamily 5, group A, member 1

Synonyms

Ad4BP; ELP; ELP-3; Ftz-F1; Ftzf1; SF-1; SF1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026751

Encoded Proteins

IDBP-166786

nuclear receptor subfamily 5, group A, member 1

IDBP-255046

nuclear receptor subfamily 5, group A, member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136931:
The protein encoded by this gene is a transcriptional activator involved in sex determination. The encoded protein binds DNA as a monomer. Defects in this gene are a cause of XY sex reversal with or without adrenal failure as well as adrenocortical insufficiency without ovarian defect. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:38692656-38714542

Strand

Reverse strand

Band

Transcripts

ENSMUST00000028084	ENSMUSP00000028084
ENSMUST00000112883	ENSMUSP00000108504
ENSMUST00000149690

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	17 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0008270	zinc ion binding
GO:0019899	enzyme binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001553	luteinization
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0008584	male gonad development
GO:0008585	female gonad development
GO:0009888	tissue development
GO:0010259	multicellular organismal aging
GO:0022414	reproductive process
GO:0030154	cell differentiation
GO:0030325	adrenal gland development
GO:0042445	hormone metabolic process
GO:0043401	steroid hormone mediated signaling pathway
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051457	maintenance of protein location in nucleus
GO:2000020	positive regulation of male gonad development
GO:2000195	negative regulation of female gonad development