Mus musculus Gene: Adarb1 | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-166979.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Adarb1 | ||||||||||||||||||||||
Gene Name | adenosine deaminase, RNA-specific, B1 | ||||||||||||||||||||||
Synonyms | 1700057H01Rik; Adar2; AW124433; AW558573; BB220382; D10Bwg0447e; Red1 | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000020262 | ||||||||||||||||||||||
Encoded Proteins |
adenosine deaminase, RNA-specific, B1
adenosine deaminase, RNA-specific, B1
adenosine deaminase, RNA-specific, B1
adenosine deaminase, RNA-specific, B1
adenosine deaminase, RNA-specific, B1
adenosine deaminase, RNA-specific, B1
|
||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene encodes a double-stranded-RNA-specific adenosine deaminase that is involved in editing pre-mRNAs by site-specific conversion of adenosine (A) to inosine (I). Substrates for this enzyme include ionotropic glutamate receptors (GluR2-6) and serotonin receptor (5HT2C). Studies in rodents have shown that this protein can modify its own pre-mRNA by A->I editing to create a novel acceptor splice site, alternative splicing to which results in down regulation of its protein expression. Additional splicing events result in transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] This gene encodes a double-stranded-RNA-specific adenosine deaminase that is involved in editing pre-mRNAs by site-specific conversion of adenosine (A) to inosine (I). Substrates for this enzyme include ionotropic glutamate receptors (GluR2-6) and serotonin receptor (5HT2C). Studies in rodents have shown that this protein can modify its own pre-mRNA by A->I editing to create a novel acceptor splice site, alternative splicing to which results in down regulation of its protein expression. Additional splicing events result in transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
||||||||||||||||||||||
Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 10:77290726-77418270 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | C1 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
|
||||||||||||||||||||||
Gene Ontology | |||||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||||
Biological Process |
|
||||||||||||||||||||||
Cellular Component |
|
||||||||||||||||||||||
Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
|
Gene ID
Gene Order
Not yet available
|
||||||||||||||||||||||
Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
mRNA Editing: A to I Conversion pathway
C6 deamination of adenosine pathway
Gene Expression pathway
Formation of editosomes by ADAR proteins pathway
mRNA Editing pathway
|
||||||||||||||||||||||
KEGG | |||||||||||||||||||||||
INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
C6 deamination of adenosine pathway
Formation of editosomes by ADAR proteins pathway
mRNA Editing pathway
Gene Expression pathway
mRNA Editing: A to I Conversion pathway
|
||||||||||||||||||||||
KEGG | |||||||||||||||||||||||
INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | D6RDS5 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 110532 | ||||||||||||||||||||||
UniGene | Mm.276815 Mm.396958 | ||||||||||||||||||||||
RefSeq | XM_006513065 NM_001024837 NM_130895 XM_006513062 XM_006513063 XM_006513064 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS35948 CCDS35949 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | MGI:891999 | ||||||||||||||||||||||
MGI Symbol | Adarb1 | ||||||||||||||||||||||
EMBL | AC153830 AC155176 | ||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | 110532 | ||||||||||||||||||||||