Version 5.4
Mus musculus Gene: Ctdsp1
Summary
InnateDB Gene IDBG-166987.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ctdsp1
Gene Name CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000026176
Encoded Proteins
IDBP-166989
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
IDBP-537430
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000144579:
This gene encodes a member of the small C-terminal domain phosphatase (SCP) family of nuclear phosphatases. These proteins play a role in transcriptional regulation through specific dephosphorylation of phosphoserine 5 within tandem heptapeptide repeats of the C-terminal domain of RNA polymerase II. The encoded protein plays a role in neuronal gene silencing in non-neuronal cells, and may also inhibit osteoblast differentiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:74391509-74397285
Strand Forward strand
Band C3
Transcripts
ENSMUST00000027367 ENSMUSP00000027367
ENSMUST00000141175
ENSMUST00000152659 ENSMUSP00000114526
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008420 CTD phosphatase activity
GO:0016791 phosphatase activity
GO:0046872 metal ion binding
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006470 protein dephosphorylation
GO:0045665 negative regulation of neuron differentiation
GO:0050768 negative regulation of neurogenesis
Cellular Component
GO:0005634 nucleus
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000144579
View Gene Order
ENSBTAG00000008362
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
ar_pathway
Coregulation of Androgen receptor activity
Cross-References
SwissProt P58466
TrEMBL F7AIT6 Q5I0X8
UniProt Splice Variant
Entrez Gene 227292
UniGene Mm.165042 Mm.412380
RefSeq NM_153088
OMIM
CCDS CCDS15048
HPRD
IMGT
MGI ID MGI:2654470
MGI Symbol Ctdsp1
EMBL AC098570 AK167390 AY028804 BC049184 BC065158 BC079638 CH466548
GenPept AAH49184 AAH65158 AAH79638 AAK83555 BAE39480 EDL00325
RNA Seq Atlas 227292

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca