Homo sapiens Gene: CTDSP1
Summary
InnateDB Gene IDBG-80989.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CTDSP1
Gene Name CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000144579
Encoded Proteins
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the small C-terminal domain phosphatase (SCP) family of nuclear phosphatases. These proteins play a role in transcriptional regulation through specific dephosphorylation of phosphoserine 5 within tandem heptapeptide repeats of the C-terminal domain of RNA polymerase II. The encoded protein plays a role in neuronal gene silencing in non-neuronal cells, and may also inhibit osteoblast differentiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:218398256-218405941
Strand Forward strand
Band q35
Transcripts
ENST00000273062 ENSP00000273062
ENST00000443891 ENSP00000392248
ENST00000452977 ENSP00000404301
ENST00000428361 ENSP00000403256
ENST00000431127 ENSP00000411308
ENST00000491064
ENST00000492545
ENST00000473420
ENST00000498160
ENST00000497677
ENST00000494067
ENST00000496785
ENST00000488627
ENST00000482272
ENST00000464255
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 8 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008420 CTD phosphatase activity
GO:0016791 phosphatase activity
GO:0046872 metal ion binding
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006470 protein dephosphorylation
GO:0045665 negative regulation of neuron differentiation
GO:0050768 negative regulation of neurogenesis
Cellular Component
GO:0005634 nucleus
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
Coregulation of Androgen receptor activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 58190
UniGene Hs.444468 Hs.608335 Hs.715312
RefSeq NM_001206878 NM_021198 NM_182642
HUGO HGNC:21614
OMIM 605323
CCDS CCDS2416 CCDS56166
HPRD 05615
IMGT
EMBL
GenPept
RNA Seq Atlas 58190