Version 5.4
Homo sapiens Gene: RNH1
Summary
InnateDB Gene IDBG-16724.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNH1
Gene Name ribonuclease/angiogenin inhibitor 1
Synonyms RAI; RNH
Species Homo sapiens
Ensembl Gene ENSG00000023191
Encoded Proteins
IDBP-16726
ribonuclease/angiogenin inhibitor 1
IDBP-16728
ribonuclease/angiogenin inhibitor 1
IDBP-234978
ribonuclease/angiogenin inhibitor 1
IDBP-234980
ribonuclease/angiogenin inhibitor 1
IDBP-234982
ribonuclease/angiogenin inhibitor 1
IDBP-360645
ribonuclease/angiogenin inhibitor 1
IDBP-587945
ribonuclease/angiogenin inhibitor 1
IDBP-588155
ribonuclease/angiogenin inhibitor 1
IDBP-591126
ribonuclease/angiogenin inhibitor 1
IDBP-603803
ribonuclease/angiogenin inhibitor 1
IDBP-593838
ribonuclease/angiogenin inhibitor 1
IDBP-593865
ribonuclease/angiogenin inhibitor 1
IDBP-599562
ribonuclease/angiogenin inhibitor 1
IDBP-590274
ribonuclease/angiogenin inhibitor 1
IDBP-594460
ribonuclease/angiogenin inhibitor 1
IDBP-600813
ribonuclease/angiogenin inhibitor 1
IDBP-600128
ribonuclease/angiogenin inhibitor 1
IDBP-600093
ribonuclease/angiogenin inhibitor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.[supplied by OMIM, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:494512-507300
Strand Reverse strand
Band p15.5
Transcripts
ENST00000354420 ENSP00000346402
ENST00000356187 ENSP00000348515
ENST00000397615 ENSP00000380739
ENST00000397614 ENSP00000380738
ENST00000397604 ENSP00000380729
ENST00000438658 ENSP00000416589
ENST00000534797 ENSP00000433999
ENST00000525522
ENST00000525701 ENSP00000436022
ENST00000529768 ENSP00000432170
ENST00000533410 ENSP00000435594
ENST00000524464 ENSP00000431201
ENST00000529115 ENSP00000433033
ENST00000527485 ENSP00000435748
ENST00000529368 ENSP00000435057
ENST00000529306 ENSP00000434947
ENST00000524780
ENST00000531149 ENSP00000435798
ENST00000531223
ENST00000528713
ENST00000532055 ENSP00000434971
ENST00000533592
ENST00000531540 ENSP00000432781
ENST00000526295
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 32 [view]
Protein-Protein 32 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008428 ribonuclease inhibitor activity
Biological Process
GO:0006402 mRNA catabolic process
GO:0043086 negative regulation of catalytic activity
GO:0045765 regulation of angiogenesis
Cellular Component
GO:0005737 cytoplasm
GO:0032311 angiogenin-PRI complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000038650
View Gene Order
Cross-References
SwissProt P13489
TrEMBL E9PIM9 E9PLZ3 E9PMI1 E9PMJ3 E9PR82
UniProt Splice Variant
Entrez Gene 6050
UniGene Hs.530687
RefSeq NM_203384 NM_002939 NM_203383 NM_203385 NM_203386 NM_203387 NM_203388 NM_203389
HUGO HGNC:10074
OMIM 173320
CCDS CCDS7697
HPRD 01412
IMGT
EMBL AC137894 AL161967 AY071904 BC000677 BC003506 BC011186 BC011500 BC014629 BC024037 BC047730 M22414 M36717 X13973
GenPept AAA59130 AAA60249 AAH00677 AAH03506 AAH11186 AAH11500 AAH14629 AAH24037 AAH47730 AAL60586 CAA32151 CAB82310
RNA Seq Atlas 6050

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca