InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RNH1

Summary

InnateDB Protein

IDBP-234982.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RNH1

Protein Name

ribonuclease/angiogenin inhibitor 1

Synonyms

RAI; RNH;

Species

Homo sapiens

Ensembl Protein

ENSP00000380729

InnateDB Gene

IDBG-16724 (RNH1)

Protein Structure

UniProt Annotation

Function

Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis. {ECO:0000269PubMed:12578357, ECO:0000269PubMed:14515218, ECO:0000269PubMed:17292889}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	32 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008428	ribonuclease inhibitor activity

Biological Process

GO:0006402	mRNA catabolic process
GO:0043086	negative regulation of catalytic activity
GO:0045765	regulation of angiogenesis

Cellular Component

GO:0005737	cytoplasm
GO:0032311	angiogenin-PRI complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001611 Leucine-rich repeat
IPR003590 Leucine-rich repeat, ribonuclease inhibitor subtype
IPR006553 Leucine-rich repeat, cysteine-containing subtype

PFAM

PF00560
PF13504
PF13855

PRINTS

PIRSF

SMART

SM00368
SM00367

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P13489