InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Itgb2

Summary

InnateDB Gene

IDBG-167243.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Itgb2

Gene Name

integrin beta 2

Synonyms

2E6; AI528527; Cd18; LAD; LCAMB; Lfa1; MF17

Species

Mus musculus

Ensembl Gene

ENSMUSG00000000290

Encoded Proteins

IDBP-167245

integrin beta 2

IDBP-539070

integrin beta 2

IDBP-531529

integrin beta 2

IDBP-710816

IDBP-713064

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21245270

Itgam :: Itgb2 is the principal leukocyte receptor involved in the recognition of the fungus Candida albicans. Recognition of Pra1p protein of C. albicans by Itgam :: Itgb2 plays a pivotal role in determining fungal virulence, and host response/protection against C. albicans infection.

PMID 22396536

Itgb2 is involved in cell-cell contact signalling between activated apoptotic lymphocytes and dendritic cells (DC) during the maturation of DCs. (Demonstrated in human)

PMID 22844116

Itgax::Itgb2 is a leukocyte receptor for Candida albicans and is essential for protection against fungal infections.

InnateDB Annotation from Orthologs

Summary

PMID 21245270

[Homo sapiens] ITGAM :: ITGB2 is the principal leukocyte receptor involved in the recognition of the fungus Candida albicans. Recognition of Pra1p protein of C. albicans by ITGAM :: ITGB2 plays a pivotal role in determining fungal virulence, and host response/protection against C. albicans infection. (Demonstrated in murine model)

PMID 22396536

[Homo sapiens] ITGB2 is involved in cell-cell contact signalling between activated apoptotic lymphocytes and dendritic cells (DC) during the maturation of DCs.

PMID 22844116

[Homo sapiens] ITGAX::ITGB2 is a leukocyte receptor for Candida albicans and is essential for protection against fungal infections.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160255:
The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:77530252-77565708

Strand

Forward strand

Band

Transcripts

ENSMUST00000000299	ENSMUSP00000000299
ENSMUST00000131023	ENSMUSP00000119657
ENSMUST00000130059	ENSMUSP00000118191
ENSMUST00000156644	ENSMUSP00000137865
ENSMUST00000153541	ENSMUSP00000137734

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	38 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0032403	protein complex binding
GO:0046982	protein heterodimerization activity
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0002523	leukocyte migration involved in inflammatory response
GO:0007155	cell adhesion
GO:0007159	leukocyte cell-cell adhesion
GO:0007160	cell-matrix adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007275	multicellular organismal development
GO:0007568	aging
GO:0016337	single organismal cell-cell adhesion
GO:0030101	natural killer cell activation
GO:0030593	neutrophil chemotaxis
GO:0043542	endothelial cell migration
GO:0045087	innate immune response (InnateDB)
GO:0045123	cellular extravasation
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0045766	positive regulation of angiogenesis
GO:0050798	activated T cell proliferation
GO:0051092	positive regulation of NF-kappaB transcription factor activity