InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ITGB2

Summary

InnateDB Gene

IDBG-639611.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITGB2

Gene Name

Integrin beta-2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000017060

Encoded Proteins

IDBP-691797

Integrin beta-2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 21245270

[Homo sapiens] ITGAM :: ITGB2 is the principal leukocyte receptor involved in the recognition of the fungus Candida albicans. Recognition of Pra1p protein of C. albicans by ITGAM :: ITGB2 plays a pivotal role in determining fungal virulence, and host response/protection against C. albicans infection. (Demonstrated in murine model)

PMID 22396536

[Homo sapiens] ITGB2 is involved in cell-cell contact signalling between activated apoptotic lymphocytes and dendritic cells (DC) during the maturation of DCs.

PMID 22844116

[Homo sapiens] ITGAX::ITGB2 is a leukocyte receptor for Candida albicans and is essential for protection against fungal infections.

PMID 21245270

[Mus musculus] Itgam :: Itgb2 is the principal leukocyte receptor involved in the recognition of the fungus Candida albicans. Recognition of Pra1p protein of C. albicans by Itgam :: Itgb2 plays a pivotal role in determining fungal virulence, and host response/protection against C. albicans infection.

PMID 22396536

[Mus musculus] Itgb2 is involved in cell-cell contact signalling between activated apoptotic lymphocytes and dendritic cells (DC) during the maturation of DCs. (Demonstrated in human)

PMID 22844116

[Mus musculus] Itgax::Itgb2 is a leukocyte receptor for Candida albicans and is essential for protection against fungal infections.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160255:
The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:145104446-145133581

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000022687

ENSBTAP00000022687

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.

Predicted by orthology
Total	35 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0046872	metal ion binding

Biological Process

GO:0007155	cell adhesion
GO:0007159	leukocyte cell-cell adhesion
GO:0007160	cell-matrix adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007275	multicellular organismal development
GO:0030593	neutrophil chemotaxis
GO:0050730	regulation of peptidyl-tyrosine phosphorylation

Cellular Component

GO:0008305	integrin complex
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043235	receptor complex
GO:0070062	extracellular vesicular exosome