Version 5.4
Mus musculus Gene: Npr1
Summary
InnateDB Gene IDBG-167260.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Npr1
Gene Name natriuretic peptide receptor 1
Synonyms AI893888; GC-A; NPR-A; NPRA; Pndr
Species Mus musculus
Ensembl Gene ENSMUSG00000027931
Encoded Proteins
IDBP-167262
natriuretic peptide receptor 1
IDBP-534612
natriuretic peptide receptor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169418:
Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:90450591-90465866
Strand Reverse strand
Band F1
Transcripts
ENSMUST00000029540 ENSMUSP00000029540
ENSMUST00000152510
ENSMUST00000142243
ENSMUST00000146991
ENSMUST00000124760 ENSMUSP00000118023
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004383 guanylate cyclase activity
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016849 phosphorus-oxygen lyase activity
GO:0016941 natriuretic peptide receptor activity
GO:0017046 peptide hormone binding
GO:0019901 protein kinase binding
GO:0042562 hormone binding
Biological Process
GO:0006182 cGMP biosynthetic process
GO:0006468 protein phosphorylation
GO:0007166 cell surface receptor signaling pathway
GO:0007168 receptor guanylyl cyclase signaling pathway
GO:0009190 cyclic nucleotide biosynthetic process
GO:0030828 positive regulation of cGMP biosynthetic process
GO:0035556 intracellular signal transduction
GO:0042417 dopamine metabolic process
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0050880 regulation of blood vessel size
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0043235 receptor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000169418
View Gene Order
ENSBTAG00000006234
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00230
Purine metabolism pathway
mmu04270
Vascular smooth muscle contraction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00230
Purine metabolism pathway
hsa04270
Vascular smooth muscle contraction pathway
INOH
INOH website
Purine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.4627
RefSeq NM_008727 XM_006501114
OMIM
CCDS CCDS17529
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca