InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.76843

Summary

InnateDB Gene

IDBG-632733.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.76843

Gene Name

atrial natriuretic peptide receptor 1 precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000006234

Encoded Proteins

IDBP-684372

Guanylate cyclase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169418:
Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:16747641-16761172

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000008184

ENSBTAP00000008184

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004383	guanylate cyclase activity
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016829	lyase activity
GO:0016849	phosphorus-oxygen lyase activity
GO:0016941	natriuretic peptide receptor activity
GO:0042562	hormone binding

Biological Process

GO:0006182	cGMP biosynthetic process
GO:0006468	protein phosphorylation
GO:0007168	receptor guanylyl cyclase signaling pathway
GO:0009190	cyclic nucleotide biosynthetic process
GO:0035556	intracellular signal transduction

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043235	receptor complex

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000169418

View Gene Order

ENSMUSG00000027931

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa00230

Purine metabolism pathway

hsa04270

Vascular smooth muscle contraction pathway

mmu00230

Purine metabolism pathway

mmu04270

Vascular smooth muscle contraction pathway

INOH

INOH website

Purine nucleotides nucleosides metabolism pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.76843

RefSeq

NM_001192751

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas