InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pdcd6

Summary

InnateDB Gene

IDBG-167307.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pdcd6

Gene Name

programmed cell death 6

Synonyms

alg-2; Alg2; AV299538; MA-3; PS2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021576

Encoded Proteins

IDBP-167309

programmed cell death 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000249915:
This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is also located on the short arm of chromosome 5. [provided by RefSeq, May 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:74303121-74317326

Strand

Reverse strand

Band

Transcripts

ENSMUST00000022060

ENSMUSP00000022060

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004198	calcium-dependent cysteine-type endopeptidase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0046983	protein dimerization activity
GO:0048306	calcium-dependent protein binding
GO:0060090	binding, bridging

Biological Process

GO:0001525	angiogenesis
GO:0001938	positive regulation of endothelial cell proliferation
GO:0006508	proteolysis
GO:0006886	intracellular protein transport
GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0010595	positive regulation of endothelial cell migration
GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0032007	negative regulation of TOR signaling
GO:0034605	cellular response to heat
GO:0036324	vascular endothelial growth factor receptor-2 signaling pathway
GO:0045766	positive regulation of angiogenesis
GO:0051592	response to calcium ion
GO:0051898	negative regulation of protein kinase B signaling

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0031410	cytoplasmic vesicle
GO:0031965	nuclear membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000249915

View Gene Order

ENSBTAG00000046493

Not yet available

Cross-References

SwissProt

P12815

TrEMBL

UniProt Splice Variant

Entrez Gene

18570

UniGene

RefSeq

NM_011051

OMIM

CCDS

CCDS26642

HPRD

IMGT

MGI ID

MGI:109283

MGI Symbol

Pdcd6

EMBL

AK008610 AK028223 AK150335 BC040079 U49112 X14938

GenPept

AAB38108 AAH40079 BAB25775 BAC25823 BAE29477 CAA33064

RNA Seq Atlas

18570