InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cysltr1

Summary

InnateDB Gene

IDBG-167323.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cysltr1

Gene Name

cysteinyl leukotriene receptor 1

Synonyms

BB147369; Cyslt1; CysLT1R

Species

Mus musculus

Ensembl Gene

ENSMUSG00000052821

Encoded Proteins

IDBP-167325

cysteinyl leukotriene receptor 1

IDBP-253811

cysteinyl leukotriene receptor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000173198:
The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR2. This encoded receptor is a member of the superfamily of G protein-coupled receptors. Activation of this receptor by LTD4 results in contraction and proliferation of smooth muscle, oedema, eosinophil migration and damage to the mucus layer in the lung. [provided by RefSeq, Jul 2008]
This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:106574346-106603679

Strand

Reverse strand

Band

Transcripts

ENSMUST00000064892	ENSMUSP00000063520
ENSMUST00000113480	ENSMUSP00000109108

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004974	leukotriene receptor activity
GO:0005515	protein binding

Biological Process

GO:0006816	calcium ion transport
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0045766	positive regulation of angiogenesis
GO:0045907	positive regulation of vasoconstriction