InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CYSLTR1

Summary

InnateDB Gene

IDBG-78021.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYSLTR1

Gene Name

cysteinyl leukotriene receptor 1

Synonyms

CYSLT1; CYSLT1R; CYSLTR; HMTMF81

Species

Homo sapiens

Ensembl Gene

ENSG00000173198

Encoded Proteins

IDBP-78023

cysteinyl leukotriene receptor 1

IDBP-810858

cysteinyl leukotriene receptor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR2. This encoded receptor is a member of the superfamily of G protein-coupled receptors. Activation of this receptor by LTD4 results in contraction and proliferation of smooth muscle, oedema, eosinophil migration and damage to the mucus layer in the lung. [provided by RefSeq, Jul 2008]
This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:78271464-78327691

Strand

Reverse strand

Band

q21.1

Transcripts

ENST00000373304	ENSP00000362401
ENST00000493254
ENST00000614798	ENSP00000478492

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004974	leukotriene receptor activity
GO:0005515	protein binding

Biological Process

GO:0006816	calcium ion transport
GO:0006935	chemotaxis
GO:0006952	defense response
GO:0006954	inflammatory response
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007585	respiratory gaseous exchange
GO:0045766	positive regulation of angiogenesis
GO:0045907	positive regulation of vasoconstriction