InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ak4

Summary

InnateDB Gene

IDBG-167445.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ak4

Gene Name

adenylate kinase 4

Synonyms

AK 4; Ak-3; Ak-4; Ak3; Ak3l1; D4Ertd274e

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028527

Encoded Proteins

IDBP-167447

adenylate kinase 4

IDBP-267712

adenylate kinase 4

IDBP-267714

adenylate kinase 4

IDBP-537813

adenylate kinase 4

IDBP-539034

adenylate kinase 4

IDBP-537941

adenylate kinase 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162433:
This gene encodes a member of the adenylate kinase family of enzymes. The encoded protein is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. A pseudogene for this gene has been located on chromosome 17. Three transcript variants encoding the same protein have been identified for this gene. Sequence alignment suggests that the gene defined by NM_013410, NM_203464, and NM_001005353 is located on chromosome 1. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:101419277-101466995

Strand

Forward strand

Band

Transcripts

ENSMUST00000102780	ENSMUSP00000099841
ENSMUST00000106946	ENSMUSP00000102559
ENSMUST00000106945	ENSMUSP00000102558
ENSMUST00000131397	ENSMUSP00000115456
ENSMUST00000133055	ENSMUSP00000115454
ENSMUST00000151561
ENSMUST00000155749	ENSMUSP00000121112

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004017	adenylate kinase activity
GO:0004550	nucleoside diphosphate kinase activity
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0016776	phosphotransferase activity, phosphate group as acceptor
GO:0046899	nucleoside triphosphate adenylate kinase activity

Biological Process

GO:0001889	liver development
GO:0006165	nucleoside diphosphate phosphorylation
GO:0007420	brain development
GO:0009142	nucleoside triphosphate biosynthetic process
GO:0042493	response to drug
GO:0046033	AMP metabolic process
GO:0046034	ATP metabolic process
GO:0046039	GTP metabolic process
GO:0046939	nucleotide phosphorylation

Cellular Component

GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000162433

View Gene Order

ENSBTAG00000030674

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu00230

Purine metabolism pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa00230

Purine metabolism pathway

INOH

INOH website

Purine nucleotides nucleosides metabolism pathway

PID NCI

Cross-References

SwissProt

Q9WUR9

TrEMBL

A2ARF6 Q3U489

UniProt Splice Variant

Entrez Gene

11639

UniGene

Mm.42040 Mm.474209

RefSeq

NM_001177602 XM_006502685 NM_001177604 NM_001177605 NM_009647

OMIM

CCDS

CCDS18394

HPRD

IMGT

MGI ID

MGI:87979

MGI Symbol

Ak4

EMBL

AB020239 AK144439 AK154374 AK166975 AL845364 BC086663 D85036

GenPept

AAH86663 BAA77363 BAA77760 BAE25891 BAE32544 BAE39158

RNA Seq Atlas

11639