InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ak4

Summary

InnateDB Protein

IDBP-167447.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ak4

Protein Name

adenylate kinase 4

Synonyms

AK 4; Ak-3; Ak-4; Ak3; Ak3l1; D4Ertd274e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099841

InnateDB Gene

IDBG-167445 (Ak4)

Protein Structure

UniProt Annotation

Function

Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. {ECO:0000255HAMAP-Rule:MF_03170}.

Subcellular Localization

Mitochondrion matrix {ECO:0000255HAMAP- Rule:MF_03170}.

Disease Associations

Tissue Specificity

Expressed in the pyramidal cells in the hippocampus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004017	adenylate kinase activity
GO:0004550	nucleoside diphosphate kinase activity
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0016776	phosphotransferase activity, phosphate group as acceptor
GO:0046899	nucleoside triphosphate adenylate kinase activity

Biological Process

GO:0001889	liver development
GO:0006165	nucleoside diphosphate phosphorylation
GO:0007420	brain development
GO:0009142	nucleoside triphosphate biosynthetic process
GO:0042493	response to drug
GO:0046033	AMP metabolic process
GO:0046034	ATP metabolic process
GO:0046039	GTP metabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix

Protein Structure and Domains

PDB ID

MGI:87979

InterPro

IPR000850 Adenylate kinase/UMP-CMP kinase
IPR006259 Adenylate kinase subfamily
IPR007862 Adenylate kinase, active site lid domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF05191

PRINTS

PR00094

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9WUR9