InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Serpina5

Summary

InnateDB Gene

IDBG-167827.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Serpina5

Gene Name

serine (or cysteine) peptidase inhibitor, clade A, member 5

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000041550

Encoded Proteins

IDBP-167829

serine (or cysteine) peptidase inhibitor, clade A, member 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000188488:
The protein encoded by this gene is a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. This gene is one in a cluster of serpin genes located on the q arm of chromosome 14. This family member is a glycoprotein that can inhibit several serine proteases, including protein C and various plasminogen activators and kallikreins, and it thus plays diverse roles in hemostasis and thrombosis in multiple organs. [provided by RefSeq, Aug 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:104101113-104106137

Strand

Forward strand

Band

Transcripts

ENSMUST00000021495

ENSMUSP00000021495

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001972	retinoic acid binding
GO:0002020	protease binding
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0031210	phosphatidylcholine binding
GO:0032190	acrosin binding

Biological Process

GO:0007283	spermatogenesis
GO:0010951	negative regulation of endopeptidase activity
GO:0030162	regulation of proteolysis
GO:0045861	negative regulation of proteolysis

Cellular Component

GO:0002080	acrosomal membrane
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0031091	platelet alpha granule
GO:0031094	platelet dense tubular network
GO:0036024	protein C inhibitor-TMPRSS7 complex
GO:0036025	protein C inhibitor-TMPRSS11E complex
GO:0036026	protein C inhibitor-PLAT complex
GO:0036027	protein C inhibitor-PLAU complex
GO:0036028	protein C inhibitor-thrombin complex
GO:0036029	protein C inhibitor-KLK3 complex
GO:0036030	protein C inhibitor-plasma kallikrein complex
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome
GO:0097181	protein C inhibitor-coagulation factor V complex
GO:0097182	protein C inhibitor-coagulation factor Xa complex
GO:0097183	protein C inhibitor-coagulation factor XI complex