Version 5.4
Homo sapiens Gene: SERPINA5
Summary
InnateDB Gene IDBG-18363.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SERPINA5
Gene Name serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
Synonyms PAI-3; PAI3; PCI; PCI-B; PLANH3; PROCI
Species Homo sapiens
Ensembl Gene ENSG00000188488
Encoded Proteins
IDBP-18365
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
IDBP-601072
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
IDBP-603144
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
IDBP-593511
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
IDBP-590800
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
IDBP-602119
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
IDBP-586923
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
IDBP-593281
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
IDBP-584238
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
IDBP-598783
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
IDBP-601931
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
IDBP-592336
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. This gene is one in a cluster of serpin genes located on the q arm of chromosome 14. This family member is a glycoprotein that can inhibit several serine proteases, including protein C and various plasminogen activators and kallikreins, and it thus plays diverse roles in hemostasis and thrombosis in multiple organs. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:94561442-94593120
Strand Forward strand
Band q32.13
Transcripts
ENST00000329597 ENSP00000333203
ENST00000554220 ENSP00000450484
ENST00000553780 ENSP00000450837
ENST00000556730
ENST00000554760 ENSP00000452469
ENST00000554866 ENSP00000451126
ENST00000556775 ENSP00000450745
ENST00000553511 ENSP00000451215
ENST00000554633 ENSP00000451697
ENST00000555681 ENSP00000451650
ENST00000554276 ENSP00000451610
ENST00000557598 ENSP00000450485
ENST00000556064 ENSP00000451487
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 16 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001972 retinoic acid binding
GO:0002020 protease binding
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005515 protein binding
GO:0005539 glycosaminoglycan binding
GO:0008201 heparin binding
GO:0031210 phosphatidylcholine binding
GO:0032190 acrosin binding
Biological Process
GO:0006869 lipid transport
GO:0007283 spermatogenesis
GO:0007342 fusion of sperm to egg plasma membrane
GO:0010951 negative regulation of endopeptidase activity
GO:0030162 regulation of proteolysis
GO:0045861 negative regulation of proteolysis
Cellular Component
GO:0002080 acrosomal membrane
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0031091 platelet alpha granule
GO:0031094 platelet dense tubular network
GO:0036024 protein C inhibitor-TMPRSS7 complex
GO:0036025 protein C inhibitor-TMPRSS11E complex
GO:0036026 protein C inhibitor-PLAT complex
GO:0036027 protein C inhibitor-PLAU complex
GO:0036028 protein C inhibitor-thrombin complex
GO:0036029 protein C inhibitor-KLK3 complex
GO:0036030 protein C inhibitor-plasma kallikrein complex
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
GO:0097181 protein C inhibitor-coagulation factor V complex
GO:0097182 protein C inhibitor-coagulation factor Xa complex
GO:0097183 protein C inhibitor-coagulation factor XI complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041550
View Gene Order
ENSBTAG00000004063
Not yet available
Pathways
NETPATH
REACTOME
REACT_326
Intrinsic Pathway pathway
REACT_1439
Common Pathway pathway
REACT_2051
Formation of Fibrin Clot (Clotting Cascade) pathway
REACT_604
Hemostasis pathway
KEGG
hsa04610
Complement and coagulation cascades pathway
INOH
PID NCI
Cross-References
SwissProt P05154
TrEMBL A0A024R6N9 G3V264 G3V265 G3V2M1 G3V3F5 G3V3Y3 G3V482 G3V4B4
UniProt Splice Variant
Entrez Gene 5104
UniGene Hs.159628 Hs.596279
RefSeq NM_000624
HUGO HGNC:8723
OMIM 601841
CCDS CCDS9928
HPRD 03503
IMGT
EMBL AF361796 AL049839 AL080185 BC008915 CH471061 J02639 M68516 S58545 S69364 S69365 S69366 S69574 U35464
GenPept AAA02811 AAA35688 AAB26244 AAB30461 AAB60386 AAH08915 AAK27240 CAB45766 EAW81582 EAW81583 EAW81584 EAW81585 EAW81586
RNA Seq Atlas 5104

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca