InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pde4b

Summary

InnateDB Gene

IDBG-167954.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pde4b

Gene Name

phosphodiesterase 4B, cAMP specific

Synonyms

Dpde4; dunce; R74983

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028525

Encoded Proteins

IDBP-167956

phosphodiesterase 4B, cAMP specific

IDBP-167958

phosphodiesterase 4B, cAMP specific

IDBP-167960

phosphodiesterase 4B, cAMP specific

IDBP-267780

phosphodiesterase 4B, cAMP specific

IDBP-267782

phosphodiesterase 4B, cAMP specific

IDBP-267784

phosphodiesterase 4B, cAMP specific

IDBP-267788

phosphodiesterase 4B, cAMP specific

IDBP-267790

phosphodiesterase 4B, cAMP specific

IDBP-627833

phosphodiesterase 4B, cAMP specific

IDBP-627835

phosphodiesterase 4B, cAMP specific

IDBP-627836

phosphodiesterase 4B, cAMP specific

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000184588:
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:102087543-102607259

Strand

Forward strand

Band

Transcripts

ENSMUST00000030251	ENSMUSP00000030251
ENSMUST00000097950	ENSMUSP00000095562
ENSMUST00000097949	ENSMUSP00000095561
ENSMUST00000106911	ENSMUSP00000102524
ENSMUST00000106908	ENSMUSP00000102521
ENSMUST00000106907	ENSMUSP00000102520
ENSMUST00000106904	ENSMUSP00000102517
ENSMUST00000106901	ENSMUSP00000102514
ENSMUST00000133632
ENSMUST00000172845
ENSMUST00000173119	ENSMUSP00000133413
ENSMUST00000174186	ENSMUSP00000134690
ENSMUST00000172616	ENSMUSP00000134340

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity
GO:0030552	cAMP binding
GO:0044325	ion channel binding
GO:0046872	metal ion binding

Biological Process

GO:0001780	neutrophil homeostasis
GO:0006198	cAMP catabolic process
GO:0007165	signal transduction
GO:0008152	metabolic process
GO:0030593	neutrophil chemotaxis
GO:0032729	positive regulation of interferon-gamma production
GO:0032743	positive regulation of interleukin-2 production
GO:0035690	cellular response to drug
GO:0050852	T cell receptor signaling pathway
GO:0050900	leukocyte migration
GO:0071222	cellular response to lipopolysaccharide
GO:0071872	cellular response to epinephrine stimulus
GO:0086004	regulation of cardiac muscle cell contraction
GO:1901841	regulation of high voltage-gated calcium channel activity
GO:1901898	negative regulation of relaxation of cardiac muscle

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005891	voltage-gated calcium channel complex
GO:0030018	Z disc
GO:0048471	perinuclear region of cytoplasm
GO:0071944	cell periphery

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000184588

View Gene Order

ENSBTAG00000008636

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu00230

Purine metabolism pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_19327

G alpha (s) signalling events pathway

REACT_15334

DARPP-32 events pathway

REACT_15295

Opioid Signalling pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

KEGG

hsa00230

Purine metabolism pathway

INOH

INOH website

Purine nucleotides nucleosides metabolism pathway

PID NCI

Cross-References

SwissProt

TrEMBL

B1AWC9 Q3TTI9

UniProt Splice Variant

Entrez Gene

18578

UniGene

Mm.20181 Mm.406096 Mm.462742 Mm.475380

RefSeq

NM_001177980 NM_001177981 NM_001177982 NM_001177983 NM_019840 XM_006502856 XM_006502858

OMIM

CCDS

CCDS18403 CCDS51243 CCDS51244 CCDS51245 CCDS57289

HPRD

IMGT

MGI ID

MGI:99557

MGI Symbol

Pde4b

EMBL

AK161341 AL732551 AL772293 AL772358 AL807794

GenPept

BAE36336

RNA Seq Atlas

18578