Version 5.4
Homo sapiens Gene: PDE4B
Summary
InnateDB Gene IDBG-99484.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDE4B
Gene Name phosphodiesterase 4B, cAMP-specific
Synonyms DPDE4; PDEIVB
Species Homo sapiens
Ensembl Gene ENSG00000184588
Encoded Proteins
IDBP-99486
phosphodiesterase 4B, cAMP-specific
IDBP-99490
phosphodiesterase 4B, cAMP-specific
IDBP-99494
phosphodiesterase 4B, cAMP-specific
IDBP-385458
phosphodiesterase 4B, cAMP-specific
IDBP-385460
phosphodiesterase 4B, cAMP-specific
IDBP-603969
phosphodiesterase 4B, cAMP-specific
IDBP-597612
phosphodiesterase 4B, cAMP-specific
IDBP-586336
phosphodiesterase 4B, cAMP-specific
IDBP-603968
phosphodiesterase 4B, cAMP-specific
IDBP-585163
phosphodiesterase 4B, cAMP-specific
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:65792514-66374579
Strand Forward strand
Band p31.3
Transcripts
ENST00000329654 ENSP00000332116
ENST00000341517 ENSP00000342637
ENST00000371048
ENST00000371045 ENSP00000360084
ENST00000412480 ENSP00000397548
ENST00000423207 ENSP00000392947
ENST00000483863
ENST00000490695
ENST00000491340 ENSP00000432400
ENST00000480109 ENSP00000432592
ENST00000531358
ENST00000532040
ENST00000526666
ENST00000528771 ENSP00000431909
ENST00000531025 ENSP00000437249
ENST00000526197 ENSP00000436104
ENST00000534463
ENST00000524999
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
GO:0030552 cAMP binding
GO:0044325 ion channel binding
GO:0046872 metal ion binding
Biological Process
GO:0001780 neutrophil homeostasis
GO:0006198 cAMP catabolic process
GO:0007165 signal transduction
GO:0030593 neutrophil chemotaxis
GO:0032729 positive regulation of interferon-gamma production
GO:0032743 positive regulation of interleukin-2 production
GO:0035690 cellular response to drug
GO:0050852 T cell receptor signaling pathway
GO:0050900 leukocyte migration
GO:0071222 cellular response to lipopolysaccharide
GO:0071872 cellular response to epinephrine stimulus
GO:0086004 regulation of cardiac muscle cell contraction
GO:1901841 regulation of high voltage-gated calcium channel activity
GO:1901898 negative regulation of relaxation of cardiac muscle
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005891 voltage-gated calcium channel complex
GO:0030018 Z disc
GO:0048471 perinuclear region of cytoplasm
GO:0071944 cell periphery
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028525
View Gene Order
ENSBTAG00000008636
Not yet available
Pathways
NETPATH
REACTOME
REACT_19327
G alpha (s) signalling events pathway
REACT_15334
DARPP-32 events pathway
REACT_15295
Opioid Signalling pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
KEGG
hsa00230
Purine metabolism pathway
INOH
INOH website
Purine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL E9PJ03 E9PNB0 E9PR34
UniProt Splice Variant
Entrez Gene 5142
UniGene Hs.198072 Hs.619276
RefSeq NM_001037339 NM_001037340 NM_001037341 NM_001297440 NM_001297441 NM_001297442 NM_002600 XM_005270923 XM_005270924 XM_005270925 XM_005270926 XM_006710680
HUGO HGNC:8781
OMIM 600127
CCDS CCDS30742 CCDS30743 CCDS632 CCDS72802
HPRD 02528
IMGT
EMBL AL109926 AL357273 AL359701 AL513493 AL590783 AL591487 AL592285
GenPept
RNA Seq Atlas 5142

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca