InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Arhgap15

Summary

InnateDB Gene

IDBG-168042.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Arhgap15

Gene Name

Rho GTPase activating protein 15

Synonyms

5830480G12Rik

Species

Mus musculus

Ensembl Gene

ENSMUSG00000049744

Encoded Proteins

IDBP-168044

Rho GTPase activating protein 15

IDBP-255168

Rho GTPase activating protein 15

IDBP-255172

Rho GTPase activating protein 15

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21551229

Arhgap15 negatively modulates Akt1 activity and thereby negatively regulates neutrophil function. Arhgap15 deficiency results in increased neutrophil recruitment to the site of infection and offers protection against an experimental model of severe abdominal sepsis.

InnateDB Annotation from Orthologs

Summary

PMID 21551229

[Homo sapiens] ARHGAP15 negatively modulates AKT1 activity and thereby negatively regulates neutrophil function. ARHGAP15 deficiency results in increased neutrophil recruitment to the site of infection and offers protection against an experimental model of severe abdominal sepsis. (Demonstrated in murine model)

Entrez Gene

Summary

The protein encoded by this gene is a RAC GTPase-activating protein that is regulated through its PH domain and by recruitment to the membrane. The protein accelerates hydrolysis of guanosine triphosphate to guanosine diphosphate to repress Rac activity. Knock-out of Arhgap15 function demonstrates that this gene is required to regulate multiple functions in macrophages and neutrophils. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:43748824-44395953

Strand

Forward strand

Band

Transcripts

ENSMUST00000055776	ENSMUSP00000056461
ENSMUST00000112824	ENSMUSP00000108443
ENSMUST00000112822	ENSMUSP00000108441
ENSMUST00000140528
ENSMUST00000128630

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0030675	Rac GTPase activator activity

Biological Process

GO:0007165	signal transduction
GO:0008360	regulation of cell shape
GO:0032855	positive regulation of Rac GTPase activity
GO:0043547	positive regulation of GTPase activity
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0016020	membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000075884

View Gene Order

ENSBTAG00000032289

Not yet available

Pathways

NETPATH

REACTOME

REACT_206918

Signaling by Rho GTPases pathway

REACT_210090

Rho GTPase cycle pathway

REACT_188257

Signal Transduction pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_11051

Rho GTPase cycle pathway

REACT_11044

Signaling by Rho GTPases pathway

REACT_111102

Signal Transduction pathway

REACT_211150

Rho GTPase cycle pathway

REACT_214353

Signal Transduction pathway

REACT_209608

Signaling by Rho GTPases pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.217350 Mm.415835

RefSeq

NM_153820 XM_006498399 XM_006498400

OMIM

CCDS

CCDS16019

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas