InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pglyrp4

Summary

InnateDB Gene

IDBG-168143.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pglyrp4

Gene Name

peptidoglycan recognition protein 4

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000042250

Encoded Proteins

IDBP-168145

peptidoglycan recognition protein 4

IDBP-623692

peptidoglycan recognition protein 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21439073

Pglyrp4 is a member of the Peptidoglycan Recognition Proteins (PGRP) family and recognizes peptidoglycan, a structural component of bacterial cell walls, as a part of innate immune response against infections.

PMID 21602801

Pglyrp4 binds to Gram-positive bacterial wall and activates a protein-sensing two-component system to induce bacterial death. PLGYRP1-mediated activation results in membrane depolarization and cessation of peptidoglycan, protein, and RNA/DNA synthesis, as well as the production of hydroxyl radicals. (Demonstrated in human)

InnateDB Annotation from Orthologs

Summary

PMID 20418257

[Homo sapiens] PGLYRP4 is a secreted innate immunity protein that is expressed on body surfaces, mucous membranes, and in secretions (saliva, sweat) and is conserved from insects to mammals, it recognizes bacterial peptidoglycan, and functions in antibacterial immunity and inflammation.

PMID 21439073

[Homo sapiens] PGLYRP4 is a member of the Peptidoglycan Recognition Proteins (PGRP) family and recognizes peptidoglycan, a structural component of bacterial cell walls, as a part of innate immune response against infections.

PMID 21602801

[Homo sapiens] PGLYRP4 binds to Gram-positive bacterial wall and activates a protein-sensing two-component system to induce bacterial death. PLGYRP1-mediated activation results in membrane depolarization and cessation of peptidoglycan, protein, and RNA/DNA synthesis, as well as the production of hydroxyl radicals.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163218:
Peptidoglycan recognition proteins, such as PGRPI-beta, are part of the innate immune system and recognize peptidoglycan, a ubiquitous component of bacterial cell walls.[supplied by OMIM, Apr 2004]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:90726906-90741517

Strand

Forward strand

Band

Transcripts

ENSMUST00000047745	ENSMUSP00000040755
ENSMUST00000156268
ENSMUST00000169698	ENSMUSP00000128113

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008270	zinc ion binding
GO:0008745	N-acetylmuramoyl-L-alanine amidase activity
GO:0016019	peptidoglycan receptor activity
GO:0042834	peptidoglycan binding

Biological Process

GO:0002221	pattern recognition receptor signaling pathway
GO:0009253	peptidoglycan catabolic process
GO:0016045	detection of bacterium
GO:0032689	negative regulation of interferon-gamma production
GO:0032827	negative regulation of natural killer cell differentiation involved in immune response
GO:0042742	defense response to bacterium
GO:0044117	growth of symbiont in host
GO:0045087	innate immune response (InnateDB)
GO:0050830	defense response to Gram-positive bacterium

Cellular Component

GO:0005575	cellular_component
GO:0005576	extracellular region

Orthologs

Species

Homo sapiens

Gene ID

Gene Order

ENSG00000163218

View Gene Order

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.316644

RefSeq

NM_001165968 NM_207263 XM_006501637

OMIM

CCDS

CCDS17544 CCDS50972

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas