InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PGLYRP4

Summary

InnateDB Gene

IDBG-102639.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PGLYRP4

Gene Name

peptidoglycan recognition protein 4

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000163218

Encoded Proteins

IDBP-102641

peptidoglycan recognition protein 4

IDBP-102643

peptidoglycan recognition protein 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20418257

PGLYRP4 is a secreted innate immunity protein that is expressed on body surfaces, mucous membranes, and in secretions (saliva, sweat) and is conserved from insects to mammals, it recognizes bacterial peptidoglycan, and functions in antibacterial immunity and inflammation.

PMID 21439073

PGLYRP4 is a member of the Peptidoglycan Recognition Proteins (PGRP) family and recognizes peptidoglycan, a structural component of bacterial cell walls, as a part of innate immune response against infections.

PMID 21602801

PGLYRP4 binds to Gram-positive bacterial wall and activates a protein-sensing two-component system to induce bacterial death. PLGYRP1-mediated activation results in membrane depolarization and cessation of peptidoglycan, protein, and RNA/DNA synthesis, as well as the production of hydroxyl radicals.

InnateDB Annotation from Orthologs

Summary

PMID 21439073

[Mus musculus] Pglyrp4 is a member of the Peptidoglycan Recognition Proteins (PGRP) family and recognizes peptidoglycan, a structural component of bacterial cell walls, as a part of innate immune response against infections.

PMID 21602801

[Mus musculus] Pglyrp4 binds to Gram-positive bacterial wall and activates a protein-sensing two-component system to induce bacterial death. PLGYRP1-mediated activation results in membrane depolarization and cessation of peptidoglycan, protein, and RNA/DNA synthesis, as well as the production of hydroxyl radicals. (Demonstrated in human)

Entrez Gene

Summary

Peptidoglycan recognition proteins, such as PGRPI-beta, are part of the innate immune system and recognize peptidoglycan, a ubiquitous component of bacterial cell walls.[supplied by OMIM, Apr 2004]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:153330120-153348840

Strand

Reverse strand

Band

q21.3

Transcripts

ENST00000368739	ENSP00000357728
ENST00000359650	ENSP00000352672
ENST00000490266

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008270	zinc ion binding
GO:0008745	N-acetylmuramoyl-L-alanine amidase activity
GO:0016019	peptidoglycan receptor activity
GO:0042834	peptidoglycan binding

Biological Process

GO:0002221	pattern recognition receptor signaling pathway
GO:0009253	peptidoglycan catabolic process
GO:0016045	detection of bacterium
GO:0032689	negative regulation of interferon-gamma production
GO:0032827	negative regulation of natural killer cell differentiation involved in immune response
GO:0044117	growth of symbiont in host
GO:0045087	innate immune response (InnateDB)
GO:0050830	defense response to Gram-positive bacterium

Cellular Component

GO:0005576	extracellular region
GO:0005622	intracellular
GO:0016020	membrane

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000042250

View Gene Order

Cross-References

SwissProt

Q96LB8

TrEMBL

UniProt Splice Variant

Entrez Gene

57115

UniGene

Hs.58356

RefSeq

NM_020393

HUGO

HGNC:30015

OMIM

608198

CCDS

CCDS30871

HPRD

16298

IMGT

EMBL

AF242518 AK292203 AL591704 AY035377 BC107157 BC107158 BC142636

GenPept

AAF99599 AAI07158 AAI07159 AAI42637 AAK72485 BAF84892 CAI19492 CAI19493

RNA Seq Atlas

57115