InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GNA11

Summary

InnateDB Gene

IDBG-16830.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GNA11

Gene Name

guanine nucleotide binding protein (G protein), alpha 11 (Gq class)

Synonyms

FBH; FBH2; FHH2; GNA-11; HHC2; HYPOC2

Species

Homo sapiens

Ensembl Gene

ENSG00000088256

Encoded Proteins

IDBP-16832

guanine nucleotide binding protein (G protein), alpha 11 (Gq class)

IDBP-807509

guanine nucleotide binding protein (G protein), alpha 11 (Gq class)

IDBP-764286

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the family of guanine nucleotide-binding proteins (G proteins), which function as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes one of the alpha subunits (subunit alpha-11). Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2). Patients with HHC2 and HYPOC2 exhibit decreased or increased sensitivity, respectively, to changes in extracellular calcium concentrations. [provided by RefSeq, Dec 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:3094410-3124004

Strand

Forward strand

Band

p13.3

Transcripts

ENST00000078429	ENSP00000078429
ENST00000588401	ENSP00000479797
ENST00000591301
ENST00000586180
ENST00000586763
ENST00000587636	ENSP00000465935
ENST00000590534

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0004871	signal transducer activity
GO:0005525	GTP binding
GO:0019001	guanyl nucleotide binding
GO:0031683	G-protein beta/gamma-subunit complex binding
GO:0031826	type 2A serotonin receptor binding
GO:0046872	metal ion binding

Biological Process

GO:0001501	skeletal system development
GO:0001508	action potential
GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007507	heart development
GO:0007596	blood coagulation
GO:0030168	platelet activation
GO:0045634	regulation of melanocyte differentiation
GO:0048066	developmental pigmentation
GO:0060158	phospholipase C-activating dopamine receptor signaling pathway
GO:0071467	cellular response to pH

Cellular Component

GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0005834	heterotrimeric G-protein complex
GO:0005886	plasma membrane
GO:0070062	extracellular vesicular exosome