Version 5.4
Mus musculus Gene: Dicer1
Summary
InnateDB Gene IDBG-168384.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dicer1
Gene Name dicer 1, ribonuclease type III
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000041415
Encoded Proteins
IDBP-168388
Dicer1, Dcr-1 homolog (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22252463
Down-regulation of Dicer1 elicits an interferon response in endometrial cancer cells.
InnateDB Annotation from Orthologs
Summary
PMID 22252463
[Homo sapiens] Down-regulation of DICER1 elicits an interferon response in endometrial cancer cells.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100697:
This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:104687742-104751952
Strand Reverse strand
Band E
Transcripts
ENSMUST00000041987 ENSMUSP00000043676
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 32 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0004386 helicase activity
GO:0004525 ribonuclease III activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters
GO:0035198 miRNA binding
Biological Process
GO:0001525 angiogenesis
GO:0001942 hair follicle development
GO:0006396 RNA processing
GO:0008283 cell proliferation
GO:0009791 post-embryonic development
GO:0010070 zygote asymmetric cell division
GO:0010468 regulation of gene expression
GO:0010628 positive regulation of gene expression
GO:0016075 rRNA catabolic process
GO:0019827 stem cell maintenance
GO:0021522 spinal cord motor neuron differentiation
GO:0021889 olfactory bulb interneuron differentiation
GO:0021987 cerebral cortex development
GO:0030324 lung development
GO:0030326 embryonic limb morphogenesis
GO:0030422 production of siRNA involved in RNA interference
GO:0030423 targeting of mRNA for destruction involved in RNA interference
GO:0031054 pre-miRNA processing
GO:0031069 hair follicle morphogenesis
GO:0031641 regulation of myelination
GO:0031643 positive regulation of myelination
GO:0035116 embryonic hindlimb morphogenesis
GO:0035196 production of miRNAs involved in gene silencing by miRNA
GO:0035264 multicellular organism growth
GO:0042487 regulation of odontogenesis of dentin-containing tooth
GO:0045069 regulation of viral genome replication
GO:0045087 innate immune response (InnateDB)
GO:0045595 regulation of cell differentiation
GO:0045664 regulation of neuron differentiation
GO:0048255 mRNA stabilization
GO:0048536 spleen development
GO:0048565 digestive tract development
GO:0048608 reproductive structure development
GO:0048713 regulation of oligodendrocyte differentiation
GO:0048730 epidermis morphogenesis
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048856 anatomical structure development
GO:0050767 regulation of neurogenesis
GO:0051225 spindle assembly
GO:0051252 regulation of RNA metabolic process
GO:0051607 defense response to virus
GO:0051726 regulation of cell cycle
GO:0055013 cardiac muscle cell development
GO:0060119 inner ear receptor cell development
GO:0060576 intestinal epithelial cell development
GO:0070173 regulation of enamel mineralization
GO:0071335 hair follicle cell proliferation
GO:0090501 RNA phosphodiester bond hydrolysis
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
GO:2000628 regulation of miRNA metabolic process
GO:2000630 positive regulation of miRNA metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0016442 RISC complex
GO:0030424 axon
GO:0030425 dendrite
GO:0030426 growth cone
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000100697
View Gene Order
ENSBTAG00000012852
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_12417
MicroRNA (miRNA) biogenesis pathway
REACT_118560
Small interfering RNA (siRNA) biogenesis pathway
REACT_71
Gene Expression pathway
REACT_12472
Regulatory RNA pathways pathway
KEGG
INOH
PID NCI
tap63pathway
Validated transcriptional targets of TAp63 isoforms
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.21135 Mm.408210 Mm.475372
RefSeq NM_148948 XM_006515608 XM_006515609 XM_006515610 XM_006515611
OMIM
CCDS CCDS36539
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca