InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dicer1

Summary

InnateDB Protein

IDBP-168388.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dicer1

Protein Name

Dicer1, Dcr-1 homolog (Drosophila)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000043676

InnateDB Gene

IDBG-168384 (Dicer1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0003725	double-stranded RNA binding
GO:0004386	helicase activity
GO:0004525	ribonuclease III activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters
GO:0035198	miRNA binding

Biological Process

GO:0001525	angiogenesis
GO:0001942	hair follicle development
GO:0006396	RNA processing
GO:0008283	cell proliferation
GO:0009791	post-embryonic development
GO:0010070	zygote asymmetric cell division
GO:0010468	regulation of gene expression
GO:0010628	positive regulation of gene expression
GO:0016075	rRNA catabolic process
GO:0019827	stem cell maintenance
GO:0021522	spinal cord motor neuron differentiation
GO:0021889	olfactory bulb interneuron differentiation
GO:0021987	cerebral cortex development
GO:0030324	lung development
GO:0030326	embryonic limb morphogenesis
GO:0030422	production of siRNA involved in RNA interference
GO:0030423	targeting of mRNA for destruction involved in RNA interference
GO:0031054	pre-miRNA processing
GO:0031069	hair follicle morphogenesis
GO:0031641	regulation of myelination
GO:0031643	positive regulation of myelination
GO:0035116	embryonic hindlimb morphogenesis
GO:0035196	production of miRNAs involved in gene silencing by miRNA
GO:0035264	multicellular organism growth
GO:0042487	regulation of odontogenesis of dentin-containing tooth
GO:0045069	regulation of viral genome replication
GO:0045087	innate immune response (InnateDB)
GO:0045595	regulation of cell differentiation
GO:0045664	regulation of neuron differentiation
GO:0048255	mRNA stabilization
GO:0048536	spleen development
GO:0048565	digestive tract development
GO:0048608	reproductive structure development
GO:0048713	regulation of oligodendrocyte differentiation
GO:0048730	epidermis morphogenesis
GO:0048754	branching morphogenesis of an epithelial tube
GO:0048856	anatomical structure development
GO:0050767	regulation of neurogenesis
GO:0051225	spindle assembly
GO:0051252	regulation of RNA metabolic process
GO:0051607	defense response to virus
GO:0051726	regulation of cell cycle
GO:0055013	cardiac muscle cell development
GO:0060119	inner ear receptor cell development
GO:0060576	intestinal epithelial cell development
GO:0070173	regulation of enamel mineralization
GO:0071335	hair follicle cell proliferation
GO:0090501	RNA phosphodiester bond hydrolysis
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic
GO:2000628	regulation of miRNA metabolic process
GO:2000630	positive regulation of miRNA metabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0016442	RISC complex
GO:0030424	axon
GO:0030425	dendrite
GO:0030426	growth cone

Protein Structure and Domains

PDB ID

MGI:2177178

InterPro

IPR000999 Ribonuclease III domain
IPR001650 Helicase, C-terminal
IPR003100 Argonaute/Dicer protein, PAZ domain
IPR005034 Dicer dimerisation domain
IPR006935 Helicase/UvrB domain
IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR014720 Double-stranded RNA-binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM