Version 5.4
Mus musculus Gene: Icosl
Summary
InnateDB Gene IDBG-168471.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Icosl
Gene Name icos ligand
Synonyms AU044799; B7-H2; B7h; B7RP-1; BG071784; GI50; GL50; GL50-B; ICOS-L; Icoslg; LICOS; Ly115l; mKIAA0653
Species Mus musculus
Ensembl Gene ENSMUSG00000000732
Encoded Proteins
IDBP-270974
icos ligand
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 26092469
Group 2 innate lymphoid cell (ILC2)-intrinsic Il33 signalling and Icosl expression promote regulatory T cell accumulation, whereas the inflammatory cytokine Ifng counter-regulated the effects of Il33, in part through direct effects on ILC2s.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 10:78069360-78079525
Strand Forward strand
Band C1
Transcripts
ENSMUST00000105393 ENSMUSP00000101032
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0042104 positive regulation of activated T cell proliferation
GO:0042110 T cell activation
GO:0045087 innate immune response (InnateDB)
GO:0045190 isotype switching
GO:0045404 positive regulation of interleukin-4 biosynthetic process
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_230745
Immune System pathway
REACT_225477
Costimulation by the CD28 family pathway
REACT_229531
Adaptive Immune System pathway
KEGG
mmu04514
Cell adhesion molecules (CAMs) pathway
mmu04672
Intestinal immune network for IgA production pathway
INOH
PID NCI
Cross-References
SwissProt Q9JHJ8
TrEMBL Q544C7
UniProt Splice Variant
Entrez Gene 50723
UniGene Mm.17819 Mm.398589
RefSeq NM_015790
OMIM
CCDS CCDS35956
HPRD
IMGT
MGI ID MGI:1354701
MGI Symbol Icosl
EMBL AF199027 AF216747 AF394451 AK041421 AX100591 AX100593 BC029227 CH466553
GenPept AAF34738 AAF45149 AAH29227 AAK77544 BAC30938 CAC36463 CAC36464 EDL31747
RNA Seq Atlas 50723

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca