InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Icosl

Summary

InnateDB Protein

IDBP-270974.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Icosl

Protein Name

icos ligand

Synonyms

AU044799; B7-H2; B7h; B7RP-1; BG071784; GI50; GL50; GL50-B; ICOS-L; Icoslg; LICOS; Ly115l; mKIAA0653;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101032

InnateDB Gene

IDBG-168471 (Icosl)

Protein Structure

UniProt Annotation

Function

Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory T-cell function. During pregnancy, may function to skew the cytokine of maternal T-cells toward immunoprotective Th2 phenotype.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Isoform 1 highest expression in lymphoid tissues, such as spleen (mostly in the marginal zone), lymph nodes (particularly in the cortex and in both primary and secondary follicles), thymus (predominantly in the medulla) and Peyer patches (mostly in the follicles), lower levels in many non- lymphoid tissues, such as brain, heart, kidney, liver, lung, skeletal muscle and testis. Present on freshly isolated splenic B- cells, T-cells, dendritic cells and macrophages. The expression of isoform 2 is restricted to heart, spleen and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding

Biological Process

GO:0007165	signal transduction
GO:0042104	positive regulation of activated T cell proliferation
GO:0042110	T cell activation
GO:0045087	innate immune response (InnateDB)
GO:0045190	isotype switching
GO:0045404	positive regulation of interleukin-4 biosynthetic process

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1354701

InterPro

IPR003597 Immunoglobulin C1-set
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
IPR013162 CD80-like, immunoglobulin C2-set

PFAM

PF07654
PF07686
PF08205

PRINTS

PIRSF

SMART

SM00407
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9JHJ8