InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Abcc2

Summary

InnateDB Gene

IDBG-168493.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Abcc2

Gene Name

ATP-binding cassette, sub-family C (CFTR/MRP), member 2

Synonyms

Abc30; AI173996; Cmoat; cMRP; Mrp2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025194

Encoded Proteins

IDBP-168495

ATP-binding cassette, sub-family C (CFTR/MRP), member 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the canalicular surface of the hepatocyte and in biliary transport, and appears to contribute to drug resistance in mammalian cells. Several different mutations in the human gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. Alternative splice variants have been observed for this gene; however, they have not been fully described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:43782192-43840740

Strand

Forward strand

Band

Transcripts

ENSMUST00000026208	ENSMUSP00000026208
ENSMUST00000143553
ENSMUST00000129943
ENSMUST00000146737

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	47 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0019904	protein domain specific binding
GO:0042626	ATPase activity, coupled to transmembrane movement of substances

Biological Process

GO:0006200	ATP catabolic process
GO:0006810	transport
GO:0006855	drug transmembrane transport
GO:0006979	response to oxidative stress
GO:0009408	response to heat
GO:0015732	prostaglandin transport
GO:0030644	cellular chloride ion homeostasis
GO:0031427	response to methotrexate
GO:0042493	response to drug
GO:0043627	response to estrogen
GO:0046685	response to arsenic-containing substance
GO:0055085	transmembrane transport
GO:0070327	thyroid hormone transport

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0046581	intercellular canaliculus

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000023839

View Gene Order

ENSBTAG00000008936

Not yet available

Pathways

NETPATH

REACTOME

REACT_253400

Transmembrane transport of small molecules pathway

REACT_237882

ABC-family proteins mediated transport pathway

KEGG

mmu02010

ABC transporters pathway

mmu04976

Bile secretion pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_15480

ABC-family proteins mediated transport pathway

REACT_15518

Transmembrane transport of small molecules pathway

KEGG

hsa02010

ABC transporters pathway

hsa04976

Bile secretion pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.39054

RefSeq

NM_013806 XM_006526625

OMIM

CCDS

CCDS29838

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas