InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Abcc2

Summary

InnateDB Protein

IDBP-168495.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Abcc2

Protein Name

ATP-binding cassette, sub-family C (CFTR/MRP), member 2

Synonyms

Abc30; AI173996; Cmoat; cMRP; Mrp2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026208

InnateDB Gene

IDBG-168493 (Abcc2)

Protein Structure

UniProt Annotation

Function

Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter (By similarity). {ECO:0000250}.

Subcellular Localization

Apical cell membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000255PROSITE-ProRule:PRU00441}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	47 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0019904	protein domain specific binding
GO:0042626	ATPase activity, coupled to transmembrane movement of substances

Biological Process

GO:0006200	ATP catabolic process
GO:0006810	transport
GO:0006855	drug transmembrane transport
GO:0006979	response to oxidative stress
GO:0009408	response to heat
GO:0015732	prostaglandin transport
GO:0030644	cellular chloride ion homeostasis
GO:0031427	response to methotrexate
GO:0042493	response to drug
GO:0043627	response to estrogen
GO:0046685	response to arsenic-containing substance
GO:0055085	transmembrane transport
GO:0070327	thyroid hormone transport

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0046581	intercellular canaliculus

Protein Structure and Domains

PDB ID

MGI:1352447

InterPro

IPR001140 ABC transporter, transmembrane domain
IPR003439 ABC transporter-like
IPR003593 AAA+ ATPase domain
IPR005292 Multi drug resistance-associated protein
IPR011527 ABC transporter type 1, transmembrane domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00664
PF13748
PF00005

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8VI47